What is the side effect of isoniazid?

What is the side effect of isoniazid?

Common side effects may include: numbness, tingling, or burning pain in your hands or feet; nausea, vomiting, upset stomach; or. abnormal liver function tests.

What is rifampin used to treat?

Rifampin is used together with other medicines to treat tuberculosis (TB) in many different parts of the body. It is also used by patients who have a meningitis bacteria in their nose or throat who do not show symptoms of the infection to prevent the spread of the bacteria to other patients.

Why pyrazinamide is used for TB?

Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What is the most serious complication of rifampin?

A severe and sometimes deadly reaction has happened. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. If you have questions, talk with the doctor. Liver problems have happened with rifampin.

How fast does rifampin work?

Rifampin is given by mouth in the form of a capsule or a compounded liquid suspension, on an empty stomach. However, if vomiting occurs, try giving the medication with food to see if it helps. This medication will take effect quickly, in about 1 to 2 hours, but its effects may not be visibly noticeable for a few days.

What are side effects of rifampin?

Rifampin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• temporary discoloration (yellow, reddish-orange, or brown color) of your skin, teeth, saliva, urine, stool, sweat, and tears)
• itching.
• flushing.
• headache.
• drowsiness.
• dizziness.
• lack of coordination.

Does rifampin cause liver damage?

Rifampin is associated with transient and asymptomatic elevations in serum aminotransferase and bilirubin levels and is a well known cause of clinically apparent, acute liver disease that can be severe and even fatal.

Why does pyrazinamide stop after 2 months?

Indeed, the use of a short, 2 month course of combination therapy with rifampin and pyrazinamide for latent tuberculosis was abandoned because of the frequency of severe liver injury with this regimen that was occasionally fatal (Case 2).

What should I avoid while taking rifampin?

Avoid drinking alcohol. It may increase your risk of liver damage. Avoid taking an antacid within 1 hour after you take Rifater. Some antacids can make it harder for your body to absorb this medicine.

What should be avoided during TB treatment?

As a TB patient, you must avoid caffeine, refined sugar and flour, sodium, and bottled sauces. Foods containing saturated and trans fats worsen the TB symptoms of diarrhoea and abdominal cramping and fatigue. Additionally, alcohol and tobacco are a definite no-no during the disease treatment and cure phase.

Can you drink milk with isoniazid?

You can take your medicine with milk, water, juice, soda, coffee or tea. If your medicine causes upset stomach, take it with food. If you are taking an antacid (like Maalox, Mylanta), take it 1 hour before or 2 hours after taking your INH.

When is the best time to take TB medication?

The medications work best if they are taken all together one hour before, or two hours after, food and preferably with water. Ideally, the medications should be taken at the same time each day. For patients who have nausea, the medications can be taken with light food (eg, dry toast).

How long does rifampin stay in the body?

In healthy adults, the mean biological half-life of rifampin in serum averages 3.35 ± 0.66 hours after a 600 mg oral dose, with increases up to 5.08 ± 2.45 hours reported after a 900 mg dose. With repeated administration, the half-life decreases and reaches average values of approximately 2 to 3 hours.