What is triptans in medical terms?

What is triptans in medical terms?

Definition of triptan : any of a class of drugs (such as sumatriptan) that bind to and are agonists of serotonin receptors and are used to treat migraine attacks.

What is an example of a triptan?

Triptans are a group (class) of medicines that are used to ease the symptoms of a migraine attack or cluster headache. They include almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan, and come in various different brand names.

What is the mechanism of action of triptans?

Mechanism of action. Their action is attributed to their agonist effects on serotonin 5-HT1B and 5-HT1D receptors in blood vessels (causing their constriction) and nerve endings in the brain, and subsequent inhibition of pro-inflammatory neuropeptide release, including CGRP and substance P.

What’s another name for eletriptan?

BRAND NAME(S): Relpax. USES: Eletriptan is used to treat migraines. It helps to relieve headache, pain, and other migraine symptoms (including nausea, vomiting, sensitivity to light/sound).

Where do triptans come from?

Continued research led to the discovery of the first triptan drug, sumatriptan, that had both vasoconstriction effect, as well as better oral bioavailability. Sumatriptan was first launched in the Netherlands in 1991 and became available in the United States during 1993.

How do triptans work on serotonin?

Triptans interact directly with some serotonin receptors in the brain. When these medications are taken together, they theoretically could cause much higher levels of serotonin and stimulation of serotonin receptors in your system than you’d experience if you were taking only one of these medications.

Is eletriptan safe?

Results: In clinical trials, eletriptan was well tolerated and safe across its dosing range of 20 mg to 80 mg. The adverse event profile of eletriptan 20 mg was similar to placebo, while the most commonly used dose, eletriptan 40 mg, has an adverse event profile that is only marginally higher than placebo.

What is the best migraine medicine?

Prescription drugs such as sumatriptan (Imitrex, Tosymra) and rizatriptan (Maxalt, Maxalt-MLT) are used to treat migraine because they block pain pathways in the brain. Taken as pills, shots or nasal sprays, they can relieve many symptoms of migraine.

What are triptans made of?

Design. All triptans have an indole structure identical to the neurotransmitter 5-HT. Classic triptan structure contain side chain on the indole ring, and a basic nitrogen in a similar distance from the indole structure.

Can triptans cause heart attacks?

Currently, there is a contraindication for the use of the triptans in patients with vascular disease, although there is no evidence that triptans increase the risk of heart attacks or stroke.

What is the role of serotonin in migraine?

Serotonin is a chemical necessary for communication between nerve cells. It can cause narrowing of blood vessels throughout the body. When serotonin or estrogen levels change, the result for some is a migraine. Serotonin levels may affect both sexes, while fluctuating estrogen levels affect women only.

Who should not take eletriptan?

You should not take this medicine if you have used other triptan or ergot-type migraine medicines within the past 24 hours. Some examples of triptan medicines are almotriptan (Axert®), frovatriptan (Frova®), naratriptan (Amerge®), rizatriptan (Maxalt®), sumatriptan (Imitrex®, Treximet®), or zolmitriptan (Zomig®).

What class of drug is eletriptan?

Eletriptan is in a class of medications called selective serotonin receptor agonists.

Can migraine be cured permanently?

There’s no cure for migraines yet. But medications can help prevent or stop them, or keep your symptoms from getting worse. You can also avoid things that trigger your migraines. Lifestyle changes like easing stress and having good sleep habits can help, too.