What is clear cell adenocarcinoma?

What is clear cell adenocarcinoma?

Listen to pronunciation. (kleer sel A-deh-noh-KAR-sih-NOH-muh) A rare type of cancer in which the cells look clear when viewed under a microscope. Clear cell adenocarcinoma occurs most often in the kidney and in the female reproductive organs.

What are symptoms of clear cell adenocarcinoma?

Some of the main signs and symptoms for clear-cell adenocarcinoma of the vagina are spotting between menstrual cycles, bleeding post-menopause, abnormal bleeding, and malignant pericardial effusion or cardiac tamponade.

What is clear cell histology?

In histology, a clear cell is a cell that shows a clear cytoplasm when stained with hematoxylin and eosin (H&E).

What causes clear cell adenocarcinoma?

Clear cell adenocarcinoma of the cervix (CCAC) is rare. The etiology and pathogenesis of the tumors are, presently, unclear. It may occur either in young women, associated with diethylstilbestrol (DES) exposure in utero from maternal use, or older women.

Why is clear cell carcinoma clear?

A person with clear cell renal cell carcinoma (ccRCC) has kidney cancer in the tubules that filter waste from blood. The cancer cells look like clear bubbles under a microscope.

What are clear cell features?

Necrosis, hemorrhage, cystic degeneration, and calcification are common; these features give the clear cell RCC its characteristic heterogeneous appearance on imaging studies. Histologically, clear cell RCC is composed of cells with abundant cytoplasm that is clear, granular, or a mixture of both.

Is clear cell carcinoma high grade?

Distinction of Clear Cell Carcinoma and Endometrioid Carcinoma. Since clear cell carcinoma is classified and managed as a high-grade carcinoma, it is important to distinguish it from low-grade endometrioid carcinoma, with which it may display morphologic overlap 82,90.

What does S100 stain?

S100 protein staining is vital in the diagnosis of cellular schwannoma, which is often mistaken for fibrosarcoma or low grade Malignant Peripheral Nerve Sheath Tumour (MPNST) [51]. MPNST shows only 50% positivity for S100 which is weak or focal staining.

What does HMB 45 stain?

HMB-45 is a widely used immunohistochemical stain for detection of primary as well as metastatic melanoma (1). Presumably, this method uses monoclonal antibodies to a glycoprotein that is present in premelanosomes (11).

What does CK7 stain?

CK7 will variably stain the majority of cells in biliary and gastric tumors. 3. Carcinomas that are almost invariably negative but may occasionally show rare CK7-positive cells include hepatomas, duodenal ampulla carcinomas, colon carcinomas, and adrenal cortical tumors.

What does SATB2 stain?

SATB2 (Special AT-rich sequence-binding protein 2) has recently been shown to be a specific biomarker of colorectal cancer (CRC). The aim of this study was to investigate the diagnostic potential of SATB2 as a means of detecting a CRC origin for liver metastases.

What stains CK20?

They observed CK7 expression in the majority of lung, breast, endometrium, ovary, cervix, salivary gland, thyroid cancers, cholangiocarcinoma, and adenocarcinoma of the pancreas. In contrast, CK20 staining was seen in all colorectal adenocarcinomas and in the majority of gastric, pancreatic, and Merkel cell tumours.

What is SATB2 a marker for?

SATB2 has gained interest as a relatively specific marker of colorectal differentiation, with potential applications including determining origin of adenocarcinomas of unknown primary and distinguishing primary ovarian mucinous adenocarcinomas from colorectal metastases.