What viruses are flaviviruses?
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What viruses are flaviviruses?
Members of this family belong to a single genus, Flavivirus, and cause widespread morbidity and mortality throughout the world. Some of the mosquitoes-transmitted viruses include: Yellow Fever, Dengue Fever, Japanese encephalitis, West Nile viruses, and Zika virus.
What is a Flavivirus disease?
Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human populations and cause a spectrum of potentially severe diseases including hepatitis, vascular shock syndrome, encephalitis, acute flaccid paralysis, congenital abnormalities and fetal death.
What is another name for the Flavivirus?
Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St.
What genome classification are the flaviviruses?
The Flaviviridae is a family of small enveloped viruses with RNA genomes of 9000–13 000 bases. Most infect mammals and birds. Many flaviviruses are host-specific and pathogenic, such as hepatitis C virus in the genus Hepacivirus.
What cells do flaviviruses infect?
An arthropod-borne flavivirus primarily infects dendritic cells, such as Langerhans cells, and keratinocytes in skin [3]. These infected cells are stimulated and then migrate into the lymph nodes [48], leading to propagation within the lymphatic system.
Where can flavivirus be found in the human body?
A flavivirus is transmitted via the bite of an infected tick or mosquito. It enters the bloodstream and invades and infects cells called monocytes in the immune system. The virus is then transported to lymph nodes and targets organs within the body, where different flaviviruses cause different symptoms.
How do flaviviruses work?
Flaviviruses are enveloped viruses, which enter their host cells through a process of receptor-mediated endocytosis and subsequent fusion from within the endosomal cell compartment. This fusion process is triggered by the mildly acidic pH within the lumen of the endosome [4].
Why are flaviviruses important human pathogens?
Arthropod-borne flaviviruses are important human pathogens that cause a diverse range of clinical conditions, including severe hemorrhagic syndromes, neurological complications and congenital malformations.
What are the symptoms of Flavivirus?
What are the symptoms of Flaviviridae? General symptoms include fever, body aches, headache, and joint pain. Some of these illness may also cause vomiting and diarrhea. The diseases caused by Flaviviridae viruses can be fatal.
Is malaria a Flavivirus?
It includes those diseases caused by alphaviruses (Barmah Forest and Ross River), flaviviruses (dengue, Murray Valley encephalitis, Kunjin, Japanese encephalitis and yellow fever) and malaria.
How do flaviviruses enter the cell?
How is Flavivirus transmitted?
Genus Flavivirus: Most members of the genus Flavivirus are transmitted by insect vectors; thus they are also often referred to as arboviruses (arthropod-borne means “transmitted by insects”).
