What is the molecular formula of paclitaxel?

What is the molecular formula of paclitaxel?

C47H51NO14Paclitaxel / Formula

What type of compound is paclitaxel?

Paclitaxel is a highly lipophilic diterpenoid compound that was first discovered in the pacific yew tree Taxus brevifolia in 1963 (Figure 6).

What is paclitaxel made up of?

Paclitaxel, the most well-known natural-source cancer drug in the United States, is derived from the bark of the Pacific yew tree (Taxus brevifolia) and is used in the treatment of breast, lung, and ovarian cancer, as well as Kaposi’s sarcoma.

What are taxanes examples?

The taxanes in clinical use include paclitaxel (Taxol, Bristol-Myers Squibb) and docetaxel (Taxotere, Sanofi-Aventis). Paclitaxel is a natural product isolated from the bark of the Western yew tree (Taxus brevifolia) and docetaxel is a semisynthetic analog (Wani et al., 1971).

Is paclitaxel a small molecule?

These small molecule paclitaxel prodrugs could self-assemble into nanoparticles in aqueous solution, which effectively improved the solubility of paclitaxel, and had certain stability in pH 6.5, pH 7.4 buffer solutions and simulated gastrointestinal fluids.

Is Taxol a Terpenoid?

Two well-known terpenoids menthol and Taxol have high economic value. For example, menthol is important in food flavorings and aroma, whereas, Taxol is best known as an anticancer medicinal. In nature these may serve as both attractants and deterrents.

Is Taxol and paclitaxel the same?

Paclitaxel is a chemotherapy drug. It is a treatment for many different types of cancer. It is also called Taxol.

What is Taxol derived?

NCI-funded research delivers a breakthrough discovery with paclitaxel (Taxol), a cancer drug from the bark of the Pacific yew tree that expands treatment options for patients with breast and ovarian cancers.

Which chemo drugs are taxanes?

Two main taxane drugs are available – paclitaxel and docetaxel. The practice of adding taxanes to standard chemotherapy has increased over the last 10 years as data from clinical trials have become available.

Is Taxol a taxane?

Taxol is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Taxol is classified as a “plant alkaloid,” a “taxane” and an “antimicrotubule agent.” (For more detail, see “How Taxol Works” section below).

Is paclitaxel a prodrug?

A series of paclitaxel prodrugs was synthesized by Dosio and co-workers [69]. All the prodrugs can self-assemble into nanoparticles in low concentration and are stable in water for several weeks.

Which of the following is terpenoid?

Well-known terpenoids include citral, menthol, camphor, salvinorin A in the plant Salvia divinorum, the cannabinoids found in cannabis, ginkgolide, and bilobalide found in Ginkgo biloba, and the curcuminoids found in turmeric and mustard seed.

What is the trade name for paclitaxel?

Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel.

What are antimitotic drugs?

(AN-tee-my-TAH-tik AY-jent) A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer.

Is nab-paclitaxel a taxane?

nab-paclitaxel: a novel formulation of taxane for treatment of breast cancer.

What are taxane drugs?

(TAK-sayn) A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer. A taxane is a type of mitotic inhibitor and a type of antimicrotubule agent.

Is atropine a terpenoid?

Particularly important (and diverse) are the alkaloids which are nitrogen containing cyclic compounds. This class includes many plant poisons and drugs: caffeine, nicotine, atropine, quinine, cocaine etc. Terpenoids are built from five-carbon isoprene units and so can also be called “isoprenoids”.