Is tolvaptan hepatotoxic?

Is tolvaptan hepatotoxic?

A rare but important side effect of tolvaptan is hepatotoxicity. Liver injury pattern characterized by tolvaptan is categorized as an idiosyncratic drug reaction and is characterized by the elevation in liver enzymes and biliary cholestasis.

Why does Legionella cause hyponatremia?

Kirby and associates (1) on legionnaires’ disease mentions hyponatremia as a common laboratory finding in their 24 patients with Legionnaires’ disease. They attribute this to possible inappropriate secretion of antidiuretic hormone secondary to bacterial pneumonia.

How does Legionella cause Siadh?

We found no evidence that increased ADH secretion would explain low sodium levels in Legionella patients, or other pneumonia patients, challenging the common believe of Legionella causing SIADH. Rather, ADH precursors were upregulated as a response to severe disease.

Can Legionnaires cause liver damage?

This is an important case that adds to growing evidence that Legionellosis can present as a multisystem disease and can lead to acute liver failure in a few select patients.

What is tolvaptan tablet used for?

Tolvaptan is used to treat hyponatremia (low sodium in the blood) in patients with heart failure or syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan is also used to slow kidney function decline in adults who are at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).

Does Legionella cause low sodium?

Low sodium levels are a common feature of patients with community-acquired pneumonia (CAP), particularly if caused by Legionella pneumophila[1-4].

Which one of the following pathogens is the most well Recognised cause of hyponatraemia?

1. Influenza Virus and other Respiratory Viruses. In general population community-acquired pneumonia (CAP) is one of the most common viral infections associated with hyponatremia.

Can mycoplasma cause hyponatremia?

A patient with chronic bronchitis and acute respiratory failure due to mycoplasma pneumonia received excess parenteral fluid and developed hyponatremia associated with generalized seizures. The low serum osmolarity and elevated urine osmolarity were consistent with SIADH.

Does Legionella cause elevated liver enzymes?

As demonstrated in Table 1, Legionella CAP patients had higher concentrations of CRP, lactate dehydrogenase (LDH) and creatinine kinase (CK), more frequently elevated liver enzymes, proteinuria and hemoglobinuria and lower concentrations of sodium, platelets and pH as compared to non-Legionella CAP patients.

What is Pontiac fever?

What is Pontiac fever? Pontiac fever is a mild flu-like illness caused by exposure to Legionella bacteria, which is found in water. It often does not require treatment.

Is tolvaptan the same as Jynarque?

Official Answer. Jynarque and Samsca both contain tolvaptan. Jynarque is used to slow kidney function decline in adults at risk of developing polycystic kidney disease. Samsca is used to help increase sodium levels in patients with heart failure, and some hormone imbalances.

What is Jynarque used for?

This medication is used by people who have a certain inherited kidney problem (autosomal dominant polycystic kidney disease-ADPKD). This inherited kidney problem leads to the growth of fluid-filled sacs (cysts) in your kidneys.

Does tolvaptan increase sodium?

Tolvaptan (Samsca) may cause the level of sodium in your blood to increase too quickly. This may cause osmotic demyelination syndrome (ODS; serious nerve damage that may be caused by quick increases in sodium levels).

What medications help hyponatremia?

Medication Summary The primary treatments used in the management of hyponatremic patients rely on the use of intravenous sodium-containing fluids (normal saline or hypertonic saline) and fluid restriction. Less commonly, loop diuretics (eg, furosemide) or demeclocycline are used.

What bacteria causes hyponatremia?

Another bacterial infection in which hyponatremia is observed is murine typhus. Its prevalence reaches up to 44% of patients, occurring more often in children than in adults [66,67].

Which pneumonia causes hyponatremia?

Background. Low sodium levels are a common feature of patients with community-acquired pneumonia (CAP), particularly if caused by Legionella pneumophila[1–4].

What is Legionellosis disease?

Legionnaires’ (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. People can get sick when they breathe in small droplets of water or accidently swallow water containing Legionella into the lungs.