What is meant by colony stimulating factor?

What is meant by colony stimulating factor?

Listen to pronunciation. (KAH-luh-nee-STIM-yoo-LAY-ting FAK-ter) A substance that stimulates the production of blood cells. Colony-stimulating factors include granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and promegapoietin.

Is colony stimulating factor a hormone?

Colony stimulating factors circulate in the blood, acting as hormones, and are also secreted locally. An example is erythropoietin, which is produced in the kidney and regulates the formation of red blood cells from progenitor cells in the bone marrow.

Is colony stimulating factor a cytokine?

The major cytokine groups are the colony stimulating factors (CSFs) and the interleukins (ILs). These substances are involved in the regulation, growth and differentiation of a variety of cellular components. Haematopoietic growth factors include the CSFs, the ILs and erythropoietin.

What would trigger the release of colony stimulating factors CSFS )? Quizlet?

They release it in response to a bacterial infection.

What is the role of the granulocyte macrophage colony stimulating factor?

Granulocyte macrophage colony-stimulating factor is a growth factor that promotes the differentiation of granulocytes and macrophages, which are critically involved in the control of the host’s defense to pathogenic microbes.

What is the function of granulocyte colony-stimulating factor?

Granulocyte colony-stimulating factor (G-CSF) is a blood growth factor (special proteins produced by the body) that stimulates the bone marrow to produce more infection-fighting white blood cells called neutrophils. Granulocyte colony-stimulating factor causes cells from the bone marrow to become mature and activated.

What cells produce granulocyte colony-stimulating factor?

G-CSF is produced by endothelium, macrophages, and a number of other immune cells. The natural human glycoprotein exists in two forms, a 174- and 177-amino-acid-long protein of molecular weight 19,600 grams per mole.

What is the difference between M-CSF and GM-CSF?

M-CSF exhibits a mostly homeostatic expression pattern, whereas GM-CSF is a product of cells activated during inflammatory or pathologic conditions. Accordingly, M-CSF regulates the numbers of various tissue macrophage and monocyte populations without altering their “activation” status.

What is G-CSF used for?

G-CSF is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant. G-CSF helps the bone marrow make more white blood cells.

What is granulocyte colony stimulating factor used for?

Granulocyte colony-stimulating factor is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant.

What does G-CSF stand for?

G-CSF is a type of growth factor. You might have G-CSF after chemotherapy to help your white blood cells recover after treatment. Or you might have it before and after a stem cell transplant.

What is granulocyte colony-stimulating factor used for?