What Does Cell Signaling Technology do?
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What Does Cell Signaling Technology do?
Cell Signaling Technology (CST) is dedicated to providing the world’s highest quality, innovative research products to accelerate biological understanding. A privately-owned company headquartered in Danvers, Massachusetts, USA. Founded in 1999, CST employs over 400 people worldwide.
What is XP in antibody?
Exceptional Sensitivity Case Study 2: Sensitivity: XP antibodies provide a strong signal for your target protein in cells and tissues, allowing you to monitor expression of low levels of endogenous proteins and use less sample to detect highly expressed target proteins.
Are room temperature antibodies stable?
As a new antibody is developed, Cell Signaling Technology (CST) scientists test the antibody’s stability and activity following a storage period of more than 7 days at -20°C, at room temperature and at 37°C. All antibodies tested have been found to be just as active and stable when stored at room temperature as on ice.
How are antibodies shipped?
The majority of our antibody products are stable at room temperature for long periods of time that are shipped in a 4ºC refrigerated packaging. Sometimes, some special products are packaged and shipped in dry ice.
Why is cell Signalling important?
Cell signaling underlies critical cellular decisions such as development, cell growth and division, differentiation, migration, apoptosis, and it essentially provides the coordination required for the functionality of multicellular organisms.
Who owns cell signaling?
Michael Comb
Cell Signaling Technology
| Type | Privately held company |
|---|---|
| Key people | Michael Comb, President and CEO, Roberto Polakiewicz, CSO, Matthew Curran, CFO, Paul Aldridge, CDO, John Letcher, SVP HR, Benjamin Comb, SVP Corporate Strategy, Simona Levi, General Counsel, Corporate Secretary, Craig Thompson, VP Global Operations |
Do antibodies expire?
Antibody storage ‘shelf life’ may range from several weeks to many years depending on both the intrinsic properties of the antibody and the storage conditions. A number of diagnostic antibodies have been shown to maintain their functionalities after 12-26 years of storage at 4°C [2].
Where are antibodies stored in the body?
For example, IgG, the most common antibody, is present mostly in the blood and tissue fluids, while IgA is found in the mucous membranes lining the respiratory and gastrointestinal tracts.
How long are antibodies stable at room temperature?
Concentrated antibodies can be stored at 2–8°C for up to 1 month. For long-term storage, we recommend that all antibodies be aliquoted into single-use amounts and stored at –20°C in a non–frost-free freezer or at –80°C.
How are antibodies stored?
Antibody conjugates are best stored at -20°C with glycerol or ethylene glycol at a final concentration of 50% for the long term. Although some enzyme conjugates may be stored at -20°C without cryoprotectants, frozen stocks must be single-use aliquots to prevent repeated freeze-thaw cycles.
Can you think of other diseases related to cell signaling?
Most of the serious diseases in humans, such as hypertension, heart disease, diabetes and many forms of mental illness, seem to arise from subtle phenotypic modifications of signalling pathways.
What diseases are caused by cell communication?
Recently it has become ap parent that a number of human diseas es, among them such diverse disorders as cholera, hyperthyroidism, myasthe nia gravis and certain types of diabe tes, arise from a common mechanism: faulty communication among cells.
How does cell signaling occur?
Cells typically receive signals in chemical form via various signaling molecules. When a signaling molecule joins with an appropriate receptor on a cell surface, this binding triggers a chain of events that not only carries the signal to the cell interior, but amplifies it as well.
Where do antibodies live in the body?
The classes of antibody differ not only in their constant region but also in activity. For example, IgG, the most common antibody, is present mostly in the blood and tissue fluids, while IgA is found in the mucous membranes lining the respiratory and gastrointestinal tracts.
How does stress affect cell signaling?
Thus, exposure to extra- or intracellular stress disrupts cellular homeostasis and causes the engagement of signaling pathways that serve to rebalance biochemical processes within the cell.
How Does asthma affect cell signaling?
The recent phenomenon has therapeutic implications related to asthma by preventing proliferation and remodeling of smooth muscle cells. Accordingly, the inhibition of the PI3K/AKT signaling pathway reduced lung inflammation by decreasing the expression of IL-4, IL-6, IL-8, TNF-α, and IgE.
