What is a transcription factor motif?

What is a transcription factor motif?

Transcription factor binding motifs (TFBMs) are genomic sequences that specifically bind to transcription factors. The consensus sequence of a TFBM is variable, and there are a number of possible bases at certain positions in the motif, whereas other positions have a fixed base.

Which motif is found in eukaryotic transcription factors?

helix-turn-helix motif
The helix-turn-helix motif (including the homeodomain proteins)

What is the EGR gene?

Entrez Gene Summary for EGR1 Gene The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis.

What is motif in DNA sequence?

Sequence motifs are short, recurring patterns in DNA that are presumed to have a biological function. Often they indicate sequence-specific binding sites for proteins such as nucleases and transcription factors (TF).

What types of DNA-binding motifs are found in transcription factors?

The common motifs include the helix-turn-helix, the homeodomain, the leucine zipper, the helix-loop-helix, and zinc fingers of several types. The precise amino acid sequence that is folded into a motif determines the particular DNA sequence that is recognized.

Which are examples of sequence motifs?

A sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance….Structural motif examples

• Zinc finger motif. Zinc fingers are a common motif in DNA-binding proteins.
• Helix-turn-helix.
• Four-helix bundle motif.
• Greek motif.
• Beta-turn.

What is a EGR protein?

EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

Where is ATF3?

Besides cancer cells, the tumor microenvironment consists of diverse cell types, including endothelial cells, immune cells, and fibroblasts. ATF3 is upregulated in the stromal compartment of several types of cancer, including colon, lung, and breast cancers (76).

What is a motif and domain?

Definition. A motif in protein structure refers to a chain-like biological structure made up of connectivity between secondary structural elements while a domain in protein structure refers to an independent folding unit of the three-dimensional protein structure.

Which of the following is a DNA binding motif?

Although each of these proteins has unique features, most bind to DNA as homodimers or heterodimers and recognize DNA through one of a small number of structural motifs. The common motifs include the helix-turn-helix, the homeodomain, the leucine zipper, the helix-loop-helix, and zinc fingers of several types.

What is the role of Sp1?

Sp1 is a ubiquitous nuclear factor that plays a key role in maintaining basal transcription of ‘house-keeping’ genes. However, recent evidence points to a more important function for Sp1 in mediating ‘cross-talk’ between selected signaling cascades to regulate the target genes that respond to these pathways.

What is zinc finger and leucine zipper?

Leucine zippers are α-helices that contain a leucine residue every seventh amino acid. This motif is found in many eukaryotic transcription factors. Zinc fingers consist of 25-30 amino acids surrounding a single zinc atom, which is coordinated by two cysteines, which are very close to short α-helices.