What is CD1c?

What is CD1c?

The antigen CD1c (BDCA-1) is a member of the CD1 family of transmembrane glycoproteins which are structurally related to major histocompatibility complex (MHC) proteins. CD1 proteins mediate presentation of lipid and glycolipid antigens, including mycobacterial cell wall components, to T cells [9].

What is CD1c a marker for?

CD1c is a frequently employed marker for DCs in man (1). CD1c is part of the MHC-like CD1 family of genes and it is involved in the presentation of lipid-based antigens to T cells (19). Importantly, while CD1c is found in many species including horses and panda bears, no murine homologue could be identified.

What DC2 4?

In general, DC2. 4 is growth factor and oncogene dependent, as it was created by retroviral transduction of bone marrow cells of C57BL/6 mice with vectors expressing murine granulocyte-macrophage CSF (GM-CSF) and the myc and raf oncogenes.

What lineage are dendritic cells?

hematopoietic lineage
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch.

What is BDCA1?

BDCA1-Positive Dendritic Cells (DCs) Represent a Unique Human Myeloid DC Subset That Induces Innate and Adaptive Immune Responses to Staphylococcus aureus Infection – PMC.

What is CD1 family?

CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. However their precise function is unknown. CD1a molecule.

Why are dendritic cells special?

Dendritic cells (DCs) are immune cells that effectively link the innate and adaptive arms of the immune system. They are considered a professional antigen-presenting cell population because of their unique capacity to induce the activation and differentiation of naive T lymphocytes.

How many types of dendritic cells are there?

Three types of DCs have been defined in human blood: the CD1c+ myeloid DCs, the CD141+ myeloid DCs and the CD303+ plasmacytoid DCs.

What does CD1 stand for?

CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells.

What are types of dendrites?

There are three main types of neurons; multipolar, bipolar, and unipolar. Multipolar neurons, such as the one shown in the image, are composed of one axon and many dendritic trees.

What is cDC1 vs cDC2?

cDC1 perform cross-presentation of antigens to MHC class I and start type I cytotoxic immune responses. cDC2 activate innate lymphoid cells 2 (ILC2) and TH2 cells and Induce ILC3 and TH17 immune responses.