What drugs cause extrapyramidal symptoms?

What drugs cause extrapyramidal symptoms?

First-generation antipsychotics commonly caused extrapyramidal symptoms. With second-generation antipsychotics, side effects tend to occur at lower rates….What causes extrapyramidal symptoms?

• chlorpromazine.
• haloperidol.
• levomepromazine.
• thioridazine.
• trifluoperazine.
• perphenazine.
• flupentixol.
• fluphenazine.

Which drug most commonly causes extrapyramidal side effects EPS?

Extrapyramidal symptoms are most commonly caused by typical antipsychotic drugs that antagonize dopamine D2 receptors. The most common typical antipsychotics associated with EPS are haloperidol and fluphenazine.

What causes neuroleptic malignant syndrome?

Neuroleptic malignant syndrome (NMS) is a severe disorder caused by an adverse reaction to medications with dopamine receptor-antagonist properties or the rapid withdrawal of dopaminergic medications.

Which antipsychotics cause more extrapyramidal symptoms?

Risperidone produced more extrapyramidal symptoms according to the SAS than quetiapine (N = 5, n = 1077, MD = 0.59, CI = 0.02–1.16, P = . 04) and ziprasidone (N = 1, n = 296, MD = 0.34, CI = 0.26–0.42, P < .

Which drug causes neuroleptic malignant syndrome?

The primary trigger of NMS is dopamine receptor blockade and the standard causative agent is an antipsychotic. Potent typical neuroleptics such as haloperidol, fluphenazine, chlorpromazine, trifluoperazine, and prochlorperazine have been most frequently associated with NMS and thought to confer the greatest risk.

Why do antipsychotics cause neuroleptic malignant syndrome?

The most widely accepted mechanism by which antipsychotics cause neuroleptic malignant syndrome is that of dopamine D2 receptor antagonism. In this model, central D2 receptor blockade in the hypothalamus, nigrostriatal pathways, and spinal cord leads to increased muscle rigidity and tremor via extrapyramidal pathways.

Which antipsychotic is least likely to cause EPS?

Of the available atypical antipsychotics, clozapine and quetiapine have shown the lowest propensity to cause extrapyramidal symptoms.

What causes neuroleptic malignant?

Why does neuroleptic malignant syndrome occur?

Causes. Neuroleptic malignant syndrome comes about, most likely, as a result of “dopamine D2 receptor antagonism”. Dopamine is a chemical substance (neurotransmitter) found in the brain and elsewhere in the central nervous system that acts to convey messages from one cell to another.

Which of the following is most likely a cause of neuroleptic malignant syndrome?

Neuroleptic malignant syndrome comes about, most likely, as a result of “dopamine D2 receptor antagonism”. Dopamine is a chemical substance (neurotransmitter) found in the brain and elsewhere in the central nervous system that acts to convey messages from one cell to another.