Which bacteria is most drug-resistant?
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Which bacteria is most drug-resistant?
Most methicillin-resistant Staphylococcus aureus, or MRSA, infections contracted outside of a hospital are skin infections. In medical centers, MRSA causes life-threatening bloodstream and surgical-site infections, as well as pneumonia. MRSA is one of the most common antibiotic-resistant bacteria.
What is New Delhi superbug?
So what exactly is this Bug. It’s called NDM1, that stands for New Delhi Metallo-1. Considered to be extremely infectious in nature, the bug is completely resistant from all antibiotics known at present.
Why is New Delhi in the name of the resistance gene NDM?
The New Delhi metallo beta-lactamase-1 (NDM-1) enzyme was named after New Delhi, the capital city of India, because it was first described by Yong et al8 in December 2009 in a Swedish national who fell ill with an antibiotic-resistant bacterial infection that he possibly acquired in India.
What does the NDM-1 gene do to bacteria?
NDM-1 stands for a gene that produces New Delhi metallo-beta-lactamase in certain bacteria that cause infections. This is a substance that destroys the commonest types of antibiotics.
What is KPC infection?
Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are a group of emerging highly drug-resistant Gram-negative bacilli causing infections associated with significant morbidity and mortality.
How is NDM treated?
The appropriate treatment of an infection caused by an NDM-1-producing multidrug-resistant bacteria usually requires double or triple antibiotic combinations; the combined use of colistin and rifampin seems more effective than monotherapy with colistin.
What is NDM antibiotic resistance?
NDM-1 refers to a gene’s protein product that some bacteria make. A bacterial strain that carries NDM-1 will be resistant to even some of the strongest antibiotics. Few current antibiotics can combat bacteria that have the NDM-1 gene, making it potentially dangerous.
How does the NDM-1 protein provide antibiotic resistance?
NDM-1 belongs to the Metallo-β-lactamase (MBL, class B) family containing Zn2+ and other divalent cations as cofactors. It inactivates almost all classes of β-lactams antibiotics including carbapenems by catalyzing the hydrolytic cleavage of the substrate amide bond.
What are the 4 superbugs?
Methicillin-resistant Staphylococcus aureus (MRSA) ESBL-producing Enterobacteriaceae (extended-spectrum β-lactamases) Vancomycin-resistant Enterococcus (VRE) Multidrug-resistant Pseudomonas aeruginosa.
What is the difference between CRE and KPC?
The term CRE refers to carbapenem-resistant and carbapenemase-producing Enterobacteriaceae. Currently, the most common type of carbapenemase in the United States is the Klebsiella pneumoniae carbapenemase (KPC).
Is KPC a real bacteria?
What is NDM in microbiology?
New Delhi metallo-β-lactamase (NDM) is a metallo-β-lactamase able to hydrolyze almost all β-lactams. Twenty-four NDM variants have been identified in >60 species of 11 bacterial families, and several variants have enhanced carbapenemase activity.
