Is indole-3-carbinol same as DIM?

Is indole-3-carbinol same as DIM?

They do come from the same source, and the majority of I3C is converted to DIM – so much so that DIM can be detectable in your blood shortly after taking I3C. However, DIM and I3C are different molecules with different (albeit similar) chemical structures.

What does I3C and DIM do?

Indole-3-carbinol (I3C) and its dimer diindolylmethane (DIM) are bioactive metabolites of a glucosinolate, glucobrassicin, found in cruciferous vegetables. Both I3C and DIM have been reported to possess pro-apoptotic, anti-proliferative and anti-carcinogenic properties via modulation of immune pathways.

Does indole-3-carbinol reduce estrogen?

I3C decreases estrogen-driven luciferase activity. Treatment with genistein results in an even greater decrease. Treatment with the two phytochemicals reduces expression significantly more than would have been predicted if the effect of the two phytochemicals were additive, which indicates a clearly synergistic effect.

What is indole-3-carbinol used for?

Indole-3-carbinol is formed when these vegetables are cut, chewed or cooked. It can also be produced in the laboratory. People use indole-3-carbinol for cancer prevention, to treat systemic lupus erythematosus (SLE), and for many other conditions, but there is no good scientific evidence to support these uses.

Should I take DIM if my estrogen is low?

Although research on DIM is still quite limited, it’s thought to help balance estrogen levels in your body ( 1 ). Specifically, DIM may stimulate the production of a less potent, more beneficial form of estrogen known as 2-hydroxyestrone ( 1 ).

Does DIM reduce estrogen?

DIM supplements appear to help adjust the hormone estrogen. A few clinical trials have shown that it supports healthy estrogen levels, lowering the risk of certain cancers and diseases like lupus that are linked to estrogen.

Can DIM cause kidney problems?

The results indicated that DIM significantly mitigated histopathological changes in the kidneys and improved the levels of blood urea nitrogen and serum creatinine. DIM also suppressed the LPS‑induced production of reactive oxygen species and cell apoptosis.

Does indole-3-carbinol balance hormones?

Indole-3-Carbinol balances hormone levels, improves breast health, detoxifies the intestines and liver, and supports the immune system.

Who should not take DIM?

Potential side effects and precautions Less common side effects include nausea, vomiting, diarrhea, and skin rash ( 3 ). As DIM supplements interact with estrogen levels, they may affect people with hormone-sensitive cancers or who are on hormone therapies.

Who should not take DIM supplement?

Is DIM hard on your liver?

DIM decreases liver infiltration of MNCs and decreases macrophage activation in the infiltrating MNCs.

Does DIM make you gain weight?

DIM should not cause weight gain. Research has found that DIM increases lipolysis (fat burning), which suggests that DIM should not cause weight gain. It may even help you lose weight if the underlying cause of those excess pounds is estrogen-related.