How was trimethoprim discovered?

How was trimethoprim discovered?

Synthesis and biological testing of various diaminopyrimidines led to the discovery in the early 1960s of trimethoprim (Scheme 8), a potent and highly selective inhibitor of the bacterial form of dihydrofolate reductase.

What is trimethoprim used for?

Trimethoprim is an antibiotic. It’s used to treat and prevent urinary tract infections (UTIs), such as cystitis. Occasionally, trimethoprim is used to treat other types of infections, such as chest infections and acne.

Is trimethoprim still being made?

Primsol is the brand name for trimethoprim available in the US. Trimpex and Proloprim are brand names that have been discontinued in the US.

Is there another name for trimethoprim?

Trimethoprim is available under the following different brand names: Primsol, Proloprim, and TMP.

Who first discovered antibiotics?

But it was not until 1928 that penicillin, the first true antibiotic, was discovered by Alexander Fleming, Professor of Bacteriology at St. Mary’s Hospital in London.

Who discovered Flagyl?

The drug was initially developed by Rhône-Poulenc in the 1950s and licensed to G.D. Searle. Searle was acquired by Pfizer in 2003.

What are the common side effects of trimethoprim?

Diarrhea, nausea, vomiting, stomach upset, loss of appetite, changes in taste, and headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Who should not take trimethoprim?

Do not give this medicine to infants or children under 12 years of age unless otherwise directed by your doctor. Trimethoprim may be taken on an empty stomach or, if it upsets your stomach, it may be taken with food.

Are amoxicillin and trimethoprim the same?

Augmentin (amoxicillin/clavulanate) and Bactrim (sulfamethoxazole and trimethoprim) are antibiotics used to treat a wide variety of bacterial infections. Augmentin and Bactrim are different types of antibiotics.

Who is the father of antibiotic?

Selman Abraham Waksman (1888-1973) was born in the rural Ukrainian town of Novaya Priluka. The town and its nearby villages were surrounded by a rich black soil that supported abundant agricultural life.

Who discovered azithromycin?

Background. Pliva is a Croatian pharmaceutical company headquartered in Zagreb. In the late 1970s, a team of Pliva’s researchers discovered an antibiotic named Azithromycin.