What is small blue round cell tumor?
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What is small blue round cell tumor?
Introduction. Small round blue cell tumours of childhood include neuroblastoma (NB), rhabdomyosarcoma, non-Hodgkin’s lymphoma, Ewing’s sarcoma and the closely related primitive neuroectodermal tumour (PNET) and the blastemic component of Wilms’ tumour.
What causes small round blue cell tumors?
Desmoplastic small round blue cell tumors (DSRCTs) originate from a cell with multilineage potential. A molecular hallmark of DSRCT is the EWS-WT1 reciprocal translocation.
What is a blue tumor?
Desmoplastic small round cell tumors (DSRCTs, sometimes also referred to as small blue round cell tumor) are a type of sarcoma that usually develops in the belly or pelvis. They are most often found in white teenagers and young men between age 10 and 30. DSRCTs may cause pain or a mass in the belly.
What is the big blue cell?
“Big blue” cells
| Likely reactive | |
|---|---|
| Chromatin | Clumped (heterochromatin) |
| Nucleoli | Absent |
| Cytoplasm | Deep smooth blue (increased RNA as producing protein), variable in amount, color, and content |
| Clinical features | Young animals, no evidence of lymphoma or leukemia |
What is malignant round cell tumor?
Malignant small round cell tumors (MSRCT) is a term used for tumors composed of malignant round cells that are slightly larger or double the size of red blood cells in air-dried smears. [1] This group of neoplasms is characterized by small, round, relatively undifferentiated cells.
What does basophil look like?
Basophils are the least numerous of the granulocytes and account for less than 1 percent of all white blood cells occurring in the human body. Their large granules stain purple-black in colour and almost completely obscure the underlying double-lobed nucleus.
How rare is DSRCT?
DSRCT is extremely rare. Fewer than 200 cases have been reported, about 85 percent of them in Caucasian people. Boys and young men are about four times as likely to have DSRCT as girls and young women. It is usually diagnosed in males between ages 10 and 30.
