What unique adverse effects are associated with cytarabine?

What unique adverse effects are associated with cytarabine?

Cytarabine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea.
• vomiting.
• diarrhea.
• stomach pain.
• loss of appetite.
• sores in the mouth and throat.
• hair loss.
• muscle or joint pain.

Is cytarabine radioactive?

After subcutaneous or intramuscular administration of cytarabine labeled with tritium, peak-plasma levels of radioactivity are achieved about 20 to 60 minutes after injection and are considerably lower than those after intravenous administration.

Is cytarabine neurotoxicity reversible?

In the past decade, neurotoxicity has been an increasingly recognized cytarabine effect. Intrathecal (IT) cytarabine may result in myelopathy that is incompletely reversible. Combined IT drug and cranial irradiation may lead to necrotizing leukoencephalopathy.

Can cytarabine cause thrombocytopenia?

The main toxic effect of cytarabine is bone marrow suppression with leukopenia, thrombocytopenia, anaemia, megaloblastosis and reduced reticulocytes.

Can cytarabine cause neuropathy?

Intravenous (IV) therapy may cause a peripheral neuropathy that varies greatly in its severity. The high IV cytarabine doses now commonly used can cause seizures, cerebral dysfunction, or an acute cerebellar syndrome with an incidence up to 14%.

What is cytarabine made from?

Cytarabine (Cytosar) is a compound isolated from a sea sponge. It has also been referred to as cytosine arabinoside and Ara-C. Cytarabine is metabolized to an active drug that inhibits DNA synthesis. Cytarabine is an anti-metabolite synthetic nucleoside analogue.

What kind of chemo is cytarabine?

Drug type: Cytarabine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “antimetabolite.” (For more detail, see “How cytarabine works” section below).

How long do cytarabine side effects last?

Dizziness, headache, excessive sleepiness, confusion, loss of balance may occur in up to 10% of patients receiving high dose therapy. Onset is usually 5 days after treatment and may last up to 1 week. More often these toxicities are mild and reversible.

Does cytarabine cause neuropathy?

Does cytarabine cause neutropenia?

On average, patients treated with HiDAC developed severe neutropenia (less than 0.5 × 109 l–1) on day 10 post high dose cytarabine administration initiation, while patients treated with IDAC achieved it on day 14.

Does drinking water help flush out chemo?

Stay well hydrated. Drinking plenty of water before and after treatment helps your body process chemotherapy drugs and flush the excess out of your system.

How long does cytarabine stay in your system?

Low blood counts. Your white and red blood cells and platelets may temporarily decrease. This can put you at risk for infection, anemia and/or bleeding. Nadir: White blood cells: 7-10 days, platelets: 12-15 days.

Does cytarabine cause hair loss?

It is also FDA approved for use with other drugs to treat acute myeloid leukemia, acute lymphoblastic leukemia and chronic myeloid leukemia. This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.