Does multiple myeloma affect the thyroid?

Does multiple myeloma affect the thyroid?

It is important to recognize that multiple myeloma is one of the causes of falsely elevated thyroid hormone levels. The monoclonal immunoglobulin can bind with T3 as suggested in our case and also T4 as shown by Cissewski et al., causing elevated total but normal free thyroid hormone levels, with a normal TSH.

Are lung and thyroid cancer related?

Thyroid gland metastasis is a rare event. Primary tumors that commonly metastasize to the thyroid include breast, lung, kidney and stomach carcinomas (1). Among lung cancer types causing thyroid metastasis, adenocarcinomas are the commonest followed by squamous and large cell carcinomas.

Can multiple myeloma metastasis to lungs?

CONCLUSIONS: Extramedullary spread of multiple myeloma to the lung is uncommon and very rarely manifests in the form of pulmonary nodules. The presence of extramedullary disease at the time of diagnosis, occurring in over half of extramedullary cases of myeloma, has been associated with poor survival.

Does multiple myeloma cause hypothyroidism?

We found that subclinical hypothyroidism occurred commonly in patients with multiple myeloma who were treated with thalidomide. This may contribute to the adverse effect profile of thalidomide, which includes constipation, fatigue, lack of energy, neuropathy, skin rash, and bradycardia. Dayan C.M.

Can thyroid affect CA125?

Conclusion: Many cases of papillary carcinoma of the thyroid show CA125 staining, and this feature therefore has little positive predictive value for an ovarian origin. Occasional cases of ovarian papillary carcinoma may show staining for thyroglobulin, and this result should therefore be interpreted cautiously.

How fast can thyroid cancer spread to the lungs?

A total of 22% of patients had metastatic thyroid cancer to other places in the body in addition to the lungs. The average follow up was 8.5 years and 85% of the patients had progression of their disease. They used the average doubling time of the two largest lung nodules for the analysis.

Where does multiple myeloma metastasize to?

Instead, populations of myeloma cells are migrating from one region of the bone marrow to another. As such, myeloma cells “invade” and “metastasize” to new sites of bone marrow.

Does myeloma affect breathing?

Myeloma protein can damage the kidneys, resulting in shortness of breath, weakness, itching, and swelling in the legs.

Do you get a cough with myeloma?

Some of the symptoms you should watch for include fever, headache, severe aches and pains, shortness of breath, dizziness, and persistent coughing. If these occur, it is likely it’s more than just a cold and you should see a doctor.

Can lymphoma affect thyroid levels?

Thyroid lymphoma can also cause hypothyroidism (see Hypothyroidism brochure), or decreased production of thyroid hormone, due to infiltration of the normal thyroid gland. The symptoms of hypothyroidism include feeling slow or tired, feeling cold, dry skin, and constipation.

Is methimazole carcinogenic?

There is inadequate evidence in humans for the carcinogenicity of methimazole. There is limited evidence in experimental animals for the carcinogenicity of methimazole. Methimazole is not classifiable as to its carcinogenicity to humans (Group 3).

What is end stage thyroid cancer?

Stage IV thyroid cancer—also called metastatic disease is cancer that has spread beyond the thyroid to the soft tissues of the neck, lymph nodes in the neck, or distant locations in the body. The lungs and bone are the most frequent sites of distant spread.

How fast does multiple myeloma spread?

How quickly multiple myeloma progresses can vary between people. An older 2007 study of 276 people found that there was a 10% risk of progression in people with early multiple myeloma per year for the first 5 years of illness.

Where does multiple myeloma spread to?

With multiple myeloma, the abnormal plasma cells grow out of control. These cells are called myeloma cells. They collect in the bone marrow and crowd out normal blood cells. They can form tumors in the bones called plasmacytomas.

What kills patients with multiple myeloma?

Steroids: These drugs are used at all stages of the disease. High doses can kill multiple myeloma cells. They’re also used to ease symptoms like pain and pressure by stopping white blood cells from racing to affected areas. And they can help with side effects of chemotherapy, like nausea and vomiting.