What is compound A in sevoflurane?

What is compound A in sevoflurane?

Sevoflurane, like all currently used volatile anaesthetics, is degraded by carbon dioxide absorbents. The most significant degradant is a haloalkene known trivially as “compound A”. Compound A is nephrotoxic in rats and, at higher doses, in nonhuman primates, causing proximal tubular necrosis.

What is the MAC of sevoflurane?

The minimum alveolar concentration (MAC) for sevoflurane required to prevent movement in response to surgical incision in healthy patients was 1.71 +/- 0.07% (SE).

Is sevoflurane metabolised in liver?

Sevoflurane is metabolized to free fluoride and hexafluoroisopropanol (HFIP). Cytochrome P450 2E1 is the major isoform responsible for sevoflurane metabolism by human liver microsomes in vitro.

Which is more potent sevoflurane or isoflurane?

Agents with nonoverlapping 95% confidence intervals are significantly different from each other ( i.e. , sevoflurane is more potent than isoflurane), as shown in table 2 .

What increases or decreases MAC?

For example, acute use of amphetamines, cocaine, ephedrine, and chronic use of alcohol increase MAC. Whereas, administration of propofol, etomidate, barbiturates, benzodiazepines, ketamine, opiates, local anesthetics, lithium, verapamil, and alpha 2-agonists (dexmedetomidine, clonidine) decrease MAC.

How is sevoflurane elimination?

Sevoflurane (SEV), a commonly used anesthetic agent for invasive surgery, is directly eliminated via exhaled breath and indirectly by metabolic conversion to inorganic fluoride and hexafluoroisopropanol (HFIP), which is also eliminated in the breath.

Does sevoflurane have high blood solubility?

c Sevoflurane Sevoflurane has a lower blood/gas partition coefficient than isoflurane, making it useful for rapid induction and fast recovery from anesthesia.

What is the MAC for sevoflurane?

How are inhaled anesthetics metabolized?

Excretion of the end product is through the kidneys, hepatobiliary system, or lungs. 6 Less than 5% of inhaled anesthetic is metabolized in the body and the elimination predominantly is through lungs, i.e. alveolus.

  • October 3, 2022