How does pox virus replicate?

How does pox virus replicate?

The DNA is replicated as long concatemers that are resolved by a viral Holliday junction endonuclease. Poxviruses are large, enveloped, DNA viruses that infect vertebrate and invertebrate species and replicate entirely in the cytoplasm (Moss 2007).

Why does pox virus replicate in cytoplasm?

Poxvirus encodes its own machinery for genome transcription, a DNA dependent RNA polymerase, which makes replication in the cytoplasm possible. Most double-stranded DNA viruses require the host cell’s DNA-dependent RNA polymerase to perform transcription.

Are pox viruses RNA or DNA?

Poxviruses are brick or oval-shaped viruses with large double-stranded DNA genomes. Poxviruses exist throughout the world and cause disease in humans and many other types of animals.

Where in the host does the smallpox virus initially replicate?

Smallpox is a double-stranded, 135- to 375-kilobase (kb) DNA virus that replicates in the cytoplasm of the host cell and forms B-type inclusion bodies (Guarnieri bodies). This is in contrast to herpes viruses, which replicate in the nucleus. The orthopoxviruses are among the largest and most complex of all viruses.

What are the types of pox?

Pox diseases occur worldwide and are caused by viruses in multiple different genera; examples include Avipoxvirus, Leporipoxvirus, Orthopoxvirus, and Parapoxvirus. Examples of pox diseases include sheep pox, horse pox, fowl pox, cowpox, goat pox, and swine pox.

What is the size of pox virus?

Poxviruses are brick-shaped (240 nm by 300 nm) and have a complex internal structure including a double-stranded DNA genome (130–260 kb) and associated enzymes. Naturally released virions have an additional outer membrane not found on infective virions extracted artificially from infected cells.

What kind of virus is pox virus?

Poxviruses are brick or oval-shaped viruses with large double-stranded DNA genomes. Poxviruses exist throughout the world and cause disease in humans and many other types of animals. Poxvirus infections typically result in the formation of lesions, skin nodules, or disseminated rash.

How fast do viruses replicate?

The reproductive cycle of viruses ranges from 8 hrs (picornaviruses) to more than 72 hrs (some herpesviruses). The virus yields per cell range from more than 100,000 poliovirus particles to several thousand poxvirus particles.

What is the most important factor for virus classification?

Because the viral genome carries the blueprint for producing new viruses, virologists consider it the most important characteristic for classification.

What are the stages of a virus life cycle?

The life cycle of virus. The virus life cycle could be divided into six steps: attachment, penetration, uncoating, gene expression and replication, assembly, and release.

What type of virus is pox virus?

Is smallpox DNA or RNA?

How are the three different classes of viruses replicate?

Virus replication will be discussed in three stages: (1) early events (attachment to susceptible cells, penetration and uncoating), (2) viral biosynthetic events (replication of the viral genome, transcription and translation) and (3) virion assembly.