What is SERCA in muscle contraction?
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What is SERCA in muscle contraction?
A key regulator of cellular calcium homeostasis is the Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump which acts to transport calcium ions from the cytosol back to the sarcoplasmic reticulum (SR) following muscle contraction.
What happens if SERCA is inhibited?
However, if SERCA is inhibited, it will slow the decay of the Ca2 + transient and the relaxation of the fish myocyte (see Fig. 4B vs C, and the normalized amplitude overlay in panel D, which highlights the kinetic effects of SR inhibition). SERCA activity is temperature dependent (see Fig. 5B).
What function does SERCA perform?
The sarcoendoplasmic reticulum (SR) calcium transport ATPase (SERCA) is a pump that transports calcium ions from the cytoplasm into the SR. It is present in both animal and plant cells, although knowledge of SERCA in the latter is scant.
What does SERCA do in skeletal muscle?
The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle.
What is SERCA?
SERCA, or sarco/endoplasmic reticulum Ca2+-ATPase, or SR Ca2+-ATPase, is a calcium ATPase-type P-ATPase. Its major function is to transport calcium from the cytosol into the sarcoplasmic reticulum.
Why is the action of SERCA required for muscle relaxation?
In muscle cells, SERCA promotes relaxation by pumping calcium ions from the cytosol into the lumen of the sarcoplasmic reticulum (SR), the main storage compartment for intracellular calcium.
Why is SERCA important for the heart?
SERCA pump serves a dual function: 1) to cause muscle relaxation by lowering cytosolic [Ca2+], and 2) to restore SR Ca2+ load necessary for muscle contraction. SERCA2a enzymatic activity is controlled by the inhibitory peptide phospholamban (PLN).
What inhibits SERCA pump?
Phospholamban is an inhibitor of SERCA pump. Therefore, an increase or a decrease in PLB level and/or its phosphorylation status can directly impact SR Ca2+ uptake function and muscle contractility.
