Is dengue related to liver?
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Is dengue related to liver?
“Dengue virus attacks the cells that cause inflammation in the liver. The Alanine Aminotransferase (ALT) and Amino Alanine Transferase (AST) enzymes increase in number in the blood during the time and may cause complications including damage to liver,“ infectious diseases and internal medicine expert Mahesh Lakhe said.
Does dengue affect liver and kidney?
Most patients with dengue fever recover following a self-limiting febrile illness, while a small proportion may progress to develop severe disease with complications such as acute liver failure, acute kidney injury, and multiorgan failure.
Can dengue cause fatty liver?
Nonalcoholic fatty liver disease is associated with increased hemoconcentration, thrombocytopenia, and longer hospital stay in dengue-infected patients with plasma leakage – PMC. The .
Which organ is affected in dengue?
The liver as a target of immune-mediated mechanisms in dengue fatal cases. The liver is considered as an important target for DENV infection and is the most common organ to be involved in the disease.
Can dengue cause elevated liver enzymes?
Infection with dengue can cause acute, febrile illness or severe disease, which can lead to plasma leakage, bleeding, and organ impairment. One of the most prominent clinical characteristics of dengue patients is increased aspartate and alanine aminotransferase liver enzyme levels.
Why is liver affected in dengue fever?
Varying degrees of liver involvement are seen during acute dengue infection and are thought to result from hepatocyte apoptosis directly by the virus, hypoxic damage due to impaired liver perfusion resulting from fluid leakage, oxidative stress or immune mediated injury [6–8].
Can dengue cause acute liver failure?
Dengue-associated acute liver failure was most common among young adults (median age, 29 years). The median duration from onset of fever to development of acute liver failure was 7.5 days. Patients with the severe stage of dengue had a higher risk of developing acute liver failure (P < 0.001).
What are the symptoms of liver swelling?
When enlarged liver results from liver disease, it might be accompanied by:
- Abdominal pain.
- Fatigue.
- Nausea and vomiting.
- Yellowing of the skin and the whites of the eyes (jaundice)
What is acute liver failure?
Acute liver failure is loss of liver function that occurs rapidly — in days or weeks — usually in a person who has no preexisting liver disease. It’s most commonly caused by a hepatitis virus or drugs, such as acetaminophen. Acute liver failure is less common than chronic liver failure, which develops more slowly.
Does dengue cause hepatitis?
A severe form of dengue fever is known as dengue hemorrhagic fever (DHF) that includes signs of hemorrhage. Besides the typical signs and symptoms, atypical presentations of dengue include myositis, hepatitis and encephalitis.
Does dengue cause jaundice?
These cases highlight that in addition to deranged liver enzymes, cholestatic pattern of jaundice may be an under recognized clinical manifestation of dengue fever. A high suspicion of dengue should be present when other supportive clinical and laboratory criteria are present in addition to that of jaundice.
What is acute liver disease?
Overview. Acute liver failure is loss of liver function that occurs rapidly — in days or weeks — usually in a person who has no preexisting liver disease. It’s most commonly caused by a hepatitis virus or drugs, such as acetaminophen.
Can dengue cause liver failure?
Involvement of the liver leading to hepatic dysfunction is a well-recognized complication of dengue [3–5]. Dengue associated acute liver failure has a high mortality due to complications such as encephalopathy, severe bleeding, renal failure and metabolic acidosis [3, 4].
How do you know liver problems?
Liver problems
- Skin and eyes that appear yellowish (jaundice)
- Abdominal pain and swelling.
- Swelling in the legs and ankles.
- Itchy skin.
- Dark urine color.
- Pale stool color.
- Chronic fatigue.
- Nausea or vomiting.
