What is Spy in surgery?

What is Spy in surgery?

SPY Portable Handheld Imager (SPY-PHI) utilizes SPY Fluorescence Imaging technology and allows surgeons to visualize blood flow in vessels and related tissue perfusion during plastic, microsurgical, reconstructive and gastrointestinal procedures.

What is SPY imaging?

Abstract. Background: SPY Elite imaging uses an injectable fluorescing agent to intraoperatively assess the perfusion and viability of tissue, including skin flaps, during postmastectomy reconstruction for breast cancer patients.

What is SPY fluorescence?

SPY Fluorescence Imaging utilizes laser generated, near infrared, light and Indocyanine Green (ICG) as the imaging agent. ICG has a well established safety profile and is processed through the liver and excreted within bile. Upon injection, the ICG binds to plasma proteins in the blood.

How does spy elite work?

The device itself has a long arm that connects to an infrared lamp device, which is used for scanning the body. A special contrast is injected into the patient’s IV line, and a TV monitor will then show scans of the breast tissue and blood vessels in real time.

How does indocyanine green work?

ICG is a tricarbocyanine dye which fluoresces, i.e. emits light, after excitation under near-infrared light at 806 nm light. ICG is highly soluble in water and binds to β-lipoproteins, particularly to albumin. Because of the high protein content of lymph, ICG accumulates in the lymphatic pathways and lymph nodes.

What is fluorescence imaging used for?

Fluorescence imaging is a type of non-invasive imaging technique that can help visualize biological processes taking place in a living organism. Images can be produced from a variety of methods including: microscopy, imaging probes, and spectroscopy.

Is ICG FDA approved?

ICG is a widely used fluorescent contrast agents in hepatic function assessment and ocular angiography. It is an FDA-approved commercial non-ionizing agent with low toxicity.

How long does ICG last in the body?

More than 95 % of ICG is captured by hepatocytes and excreted into bile within 15 min of injection [22]. Fluorescence of the liver and bile ducts can last up to 6 h after intravenous injection of ICG [21, 28].

How does fluorescence guided surgery work?

​Fluorescence-guided technology is a lifesaving imaging tool that lights up tumors and cancer cells as well as nerves and other anatomical features for easier identification and precise removal or preservation during surgeries.

Who manufactures ICG?

HUB Pharmaceuticals
Manufactured by HUB Pharmaceuticals. NDC Number: 7010042402. Comes 6 per box.

How do I prepare for ICG?

Under sterile conditions, reconstitute one (1) 25 mg vial of Indocyanine Green for Injection, USP using one (1) 10 mL Sterile Water for Injection, USP vial located in the ICG for Injection Set. Shake the ICG vial gently to dissolve.

What is ICG in laparoscopy?

Background. Bile duct injury is the most feared complication during laparoscopic cholecystectomy. Real-time intraoperative imaging using indocyanine green (ICG) might reduce the risk of bile duct injury by improving visualization of the biliary tree during laparoscopic cholecystectomy.

What is the purpose of fluorescence microscopy?

Fluorescence microscopy is highly sensitive, specific, reliable and extensively used by scientists to observe the localization of molecules within cells, and of cells within tissues.

Why is fluorescence useful?

For microscopy, fluorescence is the most useful kind of luminescence. Fluorochromes can easily be excited with their specific wavelength via specific light sources (e.g. lamps and filter systems or lasers) and the emitted light can be distinguished from the excitation light by the wavelength (Stokes’ shift).

How many exams are in the Coast Guard?

The recruitment is conducted in three phases including written exam, PET and medical examination. All candidates have to qualify these three stages for final selection in Indian Coast Guard Navik.

How is fluorescence used in medicine?

Fluorescence spectroscopy is an emerging diagnostic tool for various medical diseases including pre- malignant and malignant lesions. Fluorescence spectroscopy is a noninvasive technique and has been applied successfully for the diagnosis of multisystem cancers with high sensitivity and specificity.

How does fluorescence imaging work?

The radiation collides with the atoms in your specimen and electrons are excited to a higher energy level. When they relax to a lower level, they emit light. To become detectable (visible to the human eye) the fluorescence emitted from the sample is separated from the much brighter excitation light in a second filter.