What is non proliferative glomerulonephritis?

What is non proliferative glomerulonephritis?

Non-proliferative glomerulonephritis is characterised by a lack of glomerular cell proliferation and typically presents with nephrotic syndrome. Proliferative glomerulonephritis is characterised by increased numbers of cells in the glomerulus. It typically presents with nephritic syndrome.

What is mesangial proliferative glomerulonephritis?

Summary. Mesangial proliferative glomerulonephritis (MPGN) is a condition that affects the kidneys. It may present with nephrotic syndrome, which is a group of symptoms that include protein in the urine (proteinuria), low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling.

What causes mesangial cell proliferation?

Aberrant proliferation of mesangial cells (MCs) is a common finding in a number of diseases that can lead to end-stage renal failure. A variety of initial insults, which may be metabolic (as in diabetic nephropathy), or immunological (as in IgA disease and lupus nephritis), can cause uncontrolled MC proliferation.

What are the signs and symptoms of IgA nephropathy?

What are the symptoms of IgA nephropathy?

• Visible blood in your urine (hematuria).
• Flank pain (in the sides of your back).
• Ankle swelling (edema).
• High blood pressure (hypertension).
• Proteinuria (having too much protein in your urine), which can cause edema (swelling) and foamy urine.

What is the function of mesangial cell in kidney?

The primary function of mesangial cells is to remove trapped residues and aggregated protein from the basement membrane thus keeping the filter free of debris. The contractile properties of mesangial cells have been shown to be insignificant in changing the filtration pressure of the glomerulus.

Is IgA nephropathy a glomerulonephritis?

Immunoglobulin A (IgA) is an antibody that plays a key role in your immune system by attacking invading pathogens and fighting infections. But in IgA nephropathy, this antibody collects in the glomeruli, causing inflammation (glomerulonephritis) and gradually affecting their filtering ability.

What is the treatment for IgA nephropathy?

Medications to treat IgA nephropathy include: High blood pressure medications. Taking angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) can lower your blood pressure and reduce protein loss. Omega-3 fatty acids.