Can you take Plavix with a PPI?
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Can you take Plavix with a PPI?
Antiplatelet medication Plavix (clopidogrel) and heartburn-relieving proton pump inhibitors (PPIs) are commonly taken together. PPIs can make Plavix less effective, potentially raising your risk of a heart attack or stroke.
Which PPI to avoid with Plavix?
FDA is recommending that the co-administration of clopidogrel (Plavix), a drug used to prevent blood clot formation, and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid, be avoided because omeprazole reduces the effectiveness of clopidogrel.
Should patients on clopidogrel be on a PPI?
In May 2009, the EU Committee for Medicinal products for Human Use (CHMP) concluded that concomitant use of any PPIs with clopidogrel should be avoided unless considered essential.
What is the mechanism of interaction between Plavix and PPI?
This interaction is due to the inhibition by PPIs of the cytochrome (CYP) P450 isoenzyme 2C19, which converts clopidogrel to its active metabolite[16]. Notably, PPIs differ in their ability to inhibit CYP2C19, omeprazole being a more potent inhibitor than the other members of the class[17,18].
What acid reflux medicine is safe with Plavix?
The FDA advises that if you are experiencing heartburn or acid reflux while taking Plavix, you should try using antacids ( Maalox, Mylanta, Rolaids, Tums and generics) and most H2 blockers such as famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac), but not cimetidine (Tagamet, Tagamet HB, and generics).
What happens if you take clopidogrel and omeprazole together?
Concomitant use of omeprazole and clopidogrel was found to decrease the exposure (AUC) to clopidogrel’s active metabolite by 50% and to sharply increase platelet reactivity, as a result of inhibition by omeprazole of CYP2C19, a cytochrome P450 (CYP) enzyme.
What acid reflux medicine can be taken with Plavix?
Can you take Plavix and omeprazole together?
omeprazole clopidogrel Combining these medications may reduce the effectiveness of clopidogrel in preventing heart attack or stroke. Your doctor or pharmacist may be able to offer suggestions on safer alternatives for stomach acid or ulcer while you are being treated with clopidogrel.
Is it safe to take omeprazole with clopidogrel?
The FDA, MHRA and EMA discourage use of omeprazole and esomeprazole in patients taking clopidogrel. There is insufficient evidence regarding which PPI is least likely to interact.
