What is PI3K biology?
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What is PI3K biology?
Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
What is PI3K gene?
The PIK3CA gene provides instructions for making the p110 alpha (p110α) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K).
Is PI3K a protein kinase?
Phosphoinositide 3-kinase (PI3K) is a dual specificity kinase that is known to be involved in cell survival and malignant transformation, and it is able to phosphorylate both lipid and protein substrates.
What cancers have PIK3CA mutation?
The p110α protein is a class I PI3-kinase catalytic subunit. The human p110α protein is encoded by the PIK3CA gene. Recent evidences has demonstrated that the PIK3CA gene is mutated in a range of human cancers including: colon, ovary, breast, brain, liver, stomach and lung.
How is PIK3CA mutation treated?
PIK3CA mutation is treated with the drug alpelisib (Piqray), a targeted therapy called a PI3K inhibitor. Alpelisib (Piqray) is specifically for postmenopausal women and men with advanced breast cancer whose tumors have the PIK3CA mutation and are hormone receptor (HR) positive and HER2 negative.
How common is PIK3CA mutation?
PIK3CA gene mutations are common in breast cancer, occurring in roughly 30% to 40% of tumors, and most commonly found in estrogen receptor-positive breast cancer.
Is PIK3CA hereditary?
A PIK3CA mutation is not inherited (cannot be passed down to children). The PIK3CA gene is the most commonly mutated gene in HR+/HER2- breast cancer, affecting about 40% of people with that subtype. PIK3CA mutations have been linked to cancer growth.
What is pAKT?
Phosphorylated AKT (pAKT) is a major contributor to radioresistance in human cancers. The aim of this study was to investigate the association of pAKT expression and radiation resistance in cervical cancer.
What does PIK3CA positive mean?
PIK3CA gene mutations cause cells to grow uncontrollably, which can lead to cancer. PIK3CA gene mutations are linked to breast cancer, as well as to cancers of the ovary, lung, stomach, and brain. Breast cancer likely stems from a combination of changes to PIK3CA and other genes.
