What is Sertoli cell syndrome?

What is Sertoli cell syndrome?

Overview. Sertoli cell-only syndrome (SCO syndrome) is a cause of male infertility. In SCO syndrome, only Sertoli cells (cells that nurture the immature sperm) line the seminiferous tubules (tubes inside the testicles where sperm develop). Therefore, there are not any sperm cells present in the seminiferous tubules.

What do Sertoli cells secrete?

Sertoli cells produce and secrete the peptide hormone inhibin B into the circulation as a response to FSH stimulation.

What is the function of Sertoli cells Class 12?

Main functions of Sertoli cells are- -Sertoli cells secrete the hormones inhibin, ABP (Aromatase Binding Protein), and anti-mullerian hormone. -They together form the ‘blood testis barrier’ that stops the flow of unwanted molecules and pathogens through it.

Where are Sertoli cells found?

convoluted seminiferous tubules
Sertoli cells are found in the convoluted seminiferous tubules and form part of the blood-testis barrier in males. They also play an important role in spermatogenesis which is sperm production.

Which pituitary hormone regulate Sertoli cells?

follicle-stimulating hormone
Explanation: FSH or follicle-stimulating hormone is secreted by the anterior pituitary gland. It stimulates Sertoli cells to secrete certain factors, which are required for the spermiogenesis process, i.e. the formation of spermatozoa from spermatids.

What is Young’s syndrome?

Overview. Young syndrome is a condition characterized by male infertility, damaged airways in the lungs (bronchiectasis), and inflammation of the sinuses (sinusitis).

What is the function of inhibin?

Inhibin is a protein secreted by the Sertoli cells in men and by the granulosa cells in women. It inhibits the synthesis and release of the follicle-stimulating hormone in the pituitary gland and reduces the hypothalamic LH – releasing hormone content.

Do Sertoli cells produce ABP?

ABP is a protein found in the testicular cytosol or secreted by Sertoli cells in the rete testis fluid. It has a high affinity for androgers and binds specifically 5 alpha-DHT and testosterone (but to a lesser extent).

What are Sertoli and Leydig cells?

The Sertoli cells are normally located in the male reproductive glands (the testes). They feed sperm cells. The Leydig cells, also located in the testes, release a male sex hormone. These cells are also found in a woman’s ovaries, and in very rare cases lead to cancer.

What is Sertoli cells and Leydig cells?

Sertoli cells are the nutritive cells present inside seminiferous tubules. They provide nourishment to the male germ cells. Leydig cells are present outside the seminiferous tubules in the interstitial spaces, they secrete androgens. Sertoli cells are stimulated by FSH, whereas Leydig cells are stimulated by LH.

What is male germ cell and Sertoli cell?

Sertoli cells, the specialized epithelial cell type that surrounds the male germ line, orchestrate the organization of testicular structures and differentiation of other somatic cell linages in the testis (Leydig cells and peritubular myoid cells).

What is the origin of Sertoli cells?

Sertoli cells originate from the primitive gonads during embryonic stage and their proliferations continue throughout the pre-pubertal stage. The proliferation and final density of Sertoli cells in the testis are regulated by hormones and local factors through autocrine, paracrine as well as endocrine methods.

What gland produces oxytocin and ADH?

Posterior pituitary

Endocrine gland/ source of hormone	Hormone	Target organ or tissue
Posterior pituitary (neurohypophysis)	ADH (antidiuretic hormone)	Kidney tubules Smooth muscle in arterioles
Oxytocin	Uterine smooth muscle Mammary gland
Pineal gland	Melatonin	Various tissues
Thyroid	Thyroxine (T4) Triiodothyronine (T3)	Most tissues

What stimulates the release of FSH and LH?

GnRH
GnRH stimulates the pituitary gland to produce follicle stimulating hormone (FSH), the hormone responsible for starting follicle (egg) development and causing the level of estrogen, the primary female hormone, to rise.

Can sinus cause infertility?

An obscure sinus and lung infection called Young’s syndrome appears to be a relatively common cause of infertility in men, a study has found.

What cells produce inhibin in males?

Inhibin B is produced in the testis, principally by the Sertoli cells. There are temporal changes in inhibin expression and secretion with the changing role of the Sertoli cell in immature and adult testes. Variations in inhibin B production between species reflect the different patterns of maturation.

What stimulates release of inhibin in males?

FSH stimulation
In the human male, inhibin B is produced in the testes in response to FSH stimulation and circulates systemically to provide feedback inhibition of FSH.

What is ABP with FSH?

Production of testicular androgen binding protein (ABP), ceases following hypophysectomy and can be stimulated by FSH. Within 24 h after the administration of FSH, ABP can be measured in caput epididymis supernatant and by 4 days after FSH treatment, the concentration of ABP reaches a plateau.

What is the role of ABP?

ABP binds testosterone and transports it in the seminiferous tubule fluid to the epididymis, where it is taken up by a receptor-mediated process into the principal cells of the initial segment and caput epididymis. Once released from ABP, the testosterone is converted to DHT by the epithelial 5α-reductase.