Can osteoporosis cause iron deficiency anemia?

Can osteoporosis cause iron deficiency anemia?

Although some studies have demonstrated that anemia is associated with osteoporosis [18,19,20], the cause–effect relationship cannot be established [21] due to the limitation of a cross-sectional study design in all of the studies.

What is the first line treatment for iron deficiency anemia?

The current first line of therapy for patients with iron deficiency anemia is oral iron supplementation. Oral supplementation is cheap, safe, and effective at correcting iron deficiency anemia; however, it is not tolerated by some patients and in a subset of patients it is insufficient.

How does iron affect osteoporosis?

Iron is an essential trace element in the metabolism of almost all living organisms. Iron overload can disrupt bone homeostasis by significant inhibition of osteogenic differentiation and stimulation of osteoclastogenesis, consequently leading to osteoporosis.

Is osteoporosis related to iron?

Osteoporosis is a frequent problem in disorders characterized by iron overload, such as the thalassemias and hereditary hemochromatosis. The exact role of iron in the development of osteoporosis in these disorders is not established.

Can osteoporosis cause low blood counts?

As in our study, we found lymphocyte ratio decreased with the increase of bone loss. Similar to our study, Valderrabano et al’s found that high BMD loss was associated with decreased lymphocyte counts.

Does iron help bone density?

It has been established that iron is an important mineral for all cells, including osteoblasts, which are involved in bone formation. Several studies reported that iron overload and iron deficiency are both associated with low bone mass (1–7).

Which is the drug of choice for uncomplicated iron deficiency Anaemia?

Choice of IV formulation — A number of intravenous (IV) iron formulations are available, including ferric carboxymaltose (FCM), ferric gluconate (FG), ferumoxytol, iron sucrose (IS), ferric derisomaltose (also called iron isomaltoside), and low molecular weight iron dextran (LMW ID) (table 3).

Can too much iron cause osteoporosis?

Growing evidence suggest that excess iron disturb the delicate balance between bone resorption and bone formation which can manifest as low bone mass, osteopenia, osteoporosis, or bone fractures. Studies revealed that excess iron can influence both osteoclast and osteoblast functions.

Can osteoporosis affect blood count?

Can osteoporosis affect blood?

Blood cell counts according to three subject groups by BMD (i.e., normal, osteopenia and osteoporosis). As BMD decreases blood cell counts also gradually decrease.

Does anemia affect bone healing?

Anemia can slow or prevent fracture healing, especially in the femur and tibia, according to findings presented by Thomas F. Varecka, MD, at Orthopedics Today Hawaii 2012. When combined with anemia, Varecka noted that older age, smoking or NSAID use increased the odds of nonunion.

Does anemia affect bone density?

Chronic anemia can predispose to bone loss, the development of osteoporosis and increase the risk of fractures.

What is a critically low ferritin level?

Low ferritin: defined as ferritin levels < 30 ng/mL; normal ferritin: 30–200 ng/mL in women and 30–300 ng/mL in men; and high ferritin: >200 ng/mL in women and >300 ng/mL in men.

What is a dangerously low iron level?

What hemoglobin levels are considered severe or dangerously low? A hemoglobin level of less than 5.0 grams per deciliter (g/dl) is dangerous and could lead to heart failure or death. A normal hemoglobin level is 13.2–16.6 grams per deciliter (g/dL) for males and 11.6–15 g/dL for females.

Does collagen increase iron levels?

Peptides derived from collagen also have the ability to chelate iron.

How does hemochromatosis affect bones?

Summary: In 87 patients with hereditary hemochromatosis, osteoporosis was detected in 25%, and osteopenia in 41%. Bone mineral density was independently associated with BMI, ALP levels, hypogonadism/menopause, and the amount of iron removed to reach depletion, but not with cirrhosis.

Can osteoporosis cause low platelets?

The relationship between platelet levels and bone mineral density was then explored using statistical analysis. The results published in journal Archives of Osteoporosis indicate that high platelet counts were significantly associated with osteopenia and osteoporosis.