Does daptomycin cover MRSA?

Does daptomycin cover MRSA?

Daptomycin is used to treat various bacterial infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Daptomycin has numerous FDA-approved and off-label clinical uses.

How does daptomycin treat MRSA?

Daptomycin has concentration-dependent bactericidal activity against enterococci and staphylococci, and its spectrum of activity includes treatment of infection caused by methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus species (MRSS), glycopeptide-intermediate S.

Why is daptomycin inappropriate to treat MRSA PNA?

For the treatment of MRSA-related lung infections, including pneumonia, daptomycin is not recommended because it is inactivated by the lung surfactant (7). However, there are limited data on the effectiveness of daptomycin in MRSA hematogenous pulmonary infection.

Which antibiotic is the best choice for treating MRSA?

Vancomycin or daptomycin are the agents of choice for treatment of invasive MRSA infections [1]. Alternative agents that may be used for second-line or salvage therapy include telavancin, ceftaroline, and linezolid.

When do we not use daptomycin?

Daptomycin should not be used to treat pneumonia. This is due to the fact that daptomycin is inhibited by surfactant (Silverman et al 2005).

Why is daptomycin restricted?

The Antimicrobial Restrictions are in place due to concerns regarding a variety of issues: off-label use; the need for increased dosage for patients with bacteremia/endocarditis or other serious infections due to gram-positive pathogens; contraindication for daptomycin use in patients with pneumonia.

What should be monitored while on daptomycin?

Patients receiving daptomycin should be monitored for the development of muscle pain or weakness. Consideration should be given to temporarily suspending agents associated with rhabdomyolysis.

What is standard treatment for MRSA?

At home — Treatment of MRSA at home usually includes a 7- to 10-day course of an antibiotic (by mouth) such as trimethoprim-sulfamethoxazole (brand name: Bactrim), clindamycin, minocycline, linezolid, or doxycycline.

When should you not take daptomycin?

This medication is not recommended for use in children younger than 12 months due to possible risk of serious side effects.

When should daptomycin be discontinued?

Daptomycin should be discontinued in patients with symptoms of muscle pain or weakness whose CPK levels exceed 1000 U/L (~ 5x ULN), or in patients without symptoms whose CPK exceeds 10x ULN.

When should antibiotics be given in the treatment of MRSA?

In many cases, the person will be given antibiotics after discharge from the hospital, either by mouth or by intravenous (IV). This may be needed for a short period of time or for as long as six to eight weeks.

How long can you be on daptomycin?

aureus bacteraemia; Daptomycin is administered intravenously in 0.9 % sodium chloride (see section 6.6)….Hide table of contents.

How long does daptomycin stay in your system after stopping?

It may occur 2 months or more after you stop receiving this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.