How does Edecrin work?

How does Edecrin work?

Ethacrynic acid is a “water pill” (diuretic) that works in your kidneys to increase the amount of urine you make. This helps your body get rid of extra water. This medication is used to decrease swelling (edema) caused by conditions such as cancer, congestive heart failure, liver disease, and kidney disease.

Which actions are related to ethacrynic acid?

The primary action of ethacrynic acid is the inhibition of the activity of the Na⁺-K⁺-2Cl⁻ symporter in the thick ascending limb of the loop of Henle. The onset of action is usually within 30 minutes after an oral dose and within 5 minutes after an intravenous injection.

What is the brand name for chlorothiazide?

Trade Names/Brand Names of Chlorothiazide International- Chlotride, Diuril.

Is Edecrin Ototoxic?

However, in some patients the hearing loss has been permanent. A number of these patients were also receiving drugs known to be ototoxic. EDECRIN may increase the ototoxic potential of other drugs (see PRECAUTIONS, Drug Interactions).

What kind of diuretic is Edecrin?

Ethacrynic acid (Edecrin) is a loop diuretic (water pill) which works in the kidney to remove certain electrolytes and extra fluid from your body to lower swelling.

Is ethacrynic acid a loop diuretic?

Ethacrynic acid belongs to a group of medicines called loop diuretics or “water pills.” Ethacrynic acid is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions.

When is ethacrynic acid used?

Ethacrynic acid is used to treat edema (fluid retention; excess fluid held in body tissues) in adults and children caused by medical problems such as cancer, heart, kidney, or liver disease.

Is chlorothiazide a loop diuretic?

Thiazide Diuretics Thiazides (hydrochlorothiazide, chlorothiazide, and metolazone) are less potent than loop diuretics. Their role should be viewed as an adjunct to further augment urine output in patients already treated with a loop diuretic.

Are hydrochlorothiazide and chlorothiazide the same?

There are significant pharmacokinetic and pharmacodynamic differences between these diuretics. Chlorthalidone is ≈1.5 to 2.0 times as potent as hydrochlorothiazide, and the former has a much longer duration of action. Whether these pharmacokinetic and pharmacodynamic features cause differences in outcomes is not known.

What is the brand name for furosemide?

Brand name: Lasix. Furosemide also comes in an oral solution that you take by mouth and an injectable solution that is given by a healthcare professional. It is used to treat high blood pressure in adults.

What is the brand name for Torsemide?

Torsemide oral tablet is available as a brand-name drug and a generic drug. Brand name: Demadex. Torsemide comes in two forms: an oral tablet and an intravenous (IV) form. The IV form is only given by a healthcare provider.

Which drugs are loop diuretics?

Examples of loop diuretics include:

• Bumetanide (Bumex)
• Ethacrynic acid (Edecrin)
• Furosemide (Lasix)
• Torsemide (Soaanz)

When are loop diuretics used?

Loop diuretics are commonly used in the treatment of heart failure. In this condition, fluid accumulates in your body, due to the heart not pumping blood around the body as well as it normally would.

What are the 4 loop diuretics?

Examples

• Furosemide.
• Bumetanide.
• Ethacrynic acid.
• Torasemide.

What is the best loop diuretic?

Furosemide is by far the most common oral loop diuretic, but patients with resistance to oral furosemide therapy may benefit from trials with second-generation oral loop diuretics (bumetanide and torasemide). These may be more efficacious, due to their increased oral bioavailability and potency.

What are the side effects of ethacrynic acid?

Ethacrynic acid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• frequent urination (should not last longer than a few weeks)
• nausea.
• vomiting.
• loss of appetite.
• stomach pain.
• difficulty swallowing.
• loss of appetite.
• thirst.

What is the difference between loop and thiazide diuretics?

Thiazides decrease the urinary excretion of calcium, while loop-diuretics have the opposite effect. The possibility of loop-diuretic induced osteopenia cannot be ruled out, which should be considered when choosing between thiazides and loop-diuretics for the treatment of mild to moderate CHF.

What is an example of a loop diuretic?

Examples of loop diuretics include: Bumetanide (Bumex) Ethacrynic acid (Edecrin) Furosemide (Lasix)