What can cause hyperalgesia?
Table of Contents
What can cause hyperalgesia?
Causes of Hyperalgesia
- Surgery.
- Inflammation.
- Chemotherapy.
- Brain or spinal cord injury.
- Fibromyalgia, a disorder where you have widespread pain, along with fatigue, and memory and mood issues.
- Diabetes-induced neuropathy.
- Shingles or herpes zoster.
- Human immunodeficiency virus (HIV)
Can hyperalgesia go away?
The side effects will usually go away and you might need more medicine over time, stretched out over a long period of time to achieve the desired effect. Opioid-induced hyperalgesia (OIH) is different. Not only is there tolerance but there’s actually an anti-analgesic effect.
What is the difference between allodynia and hyperalgesia?
Allodynia is pain due to a stimulus that does not normally elicit pain. Hyperalgesia is increased pain from a stimulus that normally provokes pain.
How do you test for hyperalgesia?
A doctor may increase a person’s pain medication to determine if hyperalgesia is the cause. If the additional pain medication does cause more pain, it is possible the condition is hyperalgesia. Currently, there are no definitive diagnostic tests for hyperalgesia.
How do you reverse hyperalgesia?
Ketamine is effective in reversing hyperalgesia and augmenting the effects of opioids in patients receiving large doses, but its adverse effects prevent it from being a viable treatment option. Dextromethorphan is another NMDA receptor antagonist that has been investigated for the treatment of OIH.
How do you get rid of hyperalgesia?
Treatment of hyperalgesia can be challenging, but several options are available:
- Coming off of opioids completely. If you’re diagnosed with OIH, your doctor will prescribe doses of opioid that become gradually lower over time.
- Rotating to a different class of opioids.
- Giving an NMDA antagonist.
Can gabapentin cause hyperalgesia?
Gabapentin, a gamma-aminobutyric acid (GABA) analog anticonvulsant used to treat neuropathic pain, has been shown in animal models to reduce fentanyl hyperalgesia without compromising analgesic effect. Chronic pain patients have also exhibited lower opioid consumption and improved pain response when given gabapentin.
What is opiate hyperalgesia?
Opioid-induced hyperalgesia (OIH) is defined as a state of nociceptive sensitization caused by exposure to opioids. The condition is characterized by a paradoxical response whereby a patient receiving opioids for the treatment of pain could actually become more sensitive to certain painful stimuli.
What drugs cause allodynia?
Allodynia is pain that’s caused by something that isn’t normally painful, such as a light touch or fabric moving across your skin….Common opioids include:
- Hydrocodone.
- Oxycodone.
- Codeine.
- Morphine.
- Methadone.
- Fentanyl.
- Meperidine.
- Hydromorphone.
What triggers dysesthesia?
Dysesthesia is caused by nerve damage. When nerves are damaged, they can start to send mixed signals to your brain, resulting in unusual (and often painful) sensations. For example, you may have painful sensations in your leg even though it’s not injured.
Can I take gabapentin as needed for nerve pain?
Gabapentin is used to manage long-term (chronic) pain, not to be taken for pain as needed.
What medicine treats allodynia?
How is allodynia treated?
- oral medications, such as lidocaine (Xylocaine) or pregabalin (Lyrica)
- topical treatments, such as lidocaine ointment or a capsaicin patch.
- nonsteroidal anti-inflammatory drugs , such as naproxen (Aleve) or indomethacin.
- lifestyle changes, like exercise and dietary changes.
