What does CD155 do?

What does CD155 do?

CD155 is an adhesion molecule up-regulated during tumor progression that may favor tumor cell proliferative and migrating ability. On the other hand, CD155 represents a danger signal for the activating receptor DNAM-1 expressed on NK and T cells being implicated in tumor cell recognition and killing.

What cells have CD155?

The cell surface receptor for all three poliovirus serotypes is CD155, a glycoprotein that functions as an adhesion molecule in adherens junctions. In addition, CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the “poliovirus receptor,” or PVR.

What is CD112?

CD112 Function. Intracellular adhesion, component of adherins junctions. Receptor for herpes simplex virus. CD112 Summary. Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.[1]

Where is vitronectin found?

Vitronectin is an abundant adhesive glycoprotein in blood plasma and is found associated with different extracellular matrix sites, the vessel wall, and tumor cells, particularly upon tissue remodeling, injury/repair, or under disease conditions.

Where is Tigit expressed?

22 TIGIT binds two ligands, CD155 and CD112 (figure 1 and table 1), that are expressed on monocytes, dendritic cells (DCs), and many non-hematopoietic cells including tumor cells of different histological types.

How does poliovirus enter the cell?

By testing inhibitors known to target specific enzymes, future studies can determine which one poliovirus hijacks to infect cells. Altogether, these results suggest that the poliovirus enters the cell after binding to the cell surface, then rapidly releases it genome from vesicles near the membrane.

Is polio intracellular or extracellular?

The cellular receptor CD155 is the extracellular receptor for poliovirus. It may be identified in organs, such as the brain, heart, skeletal muscle and liver.

What is the function of vitronectin?

Vitronectin is a multifunctional glycoprotein present in blood and in the extracellular matrix. It binds glycosaminoglycans, collagen, plasminogen and the urokinase-receptor, and also stabilizes the inhibitory conformation of plasminogen activation inhibitor-1.

What is TIGIT in oncology?

Specifically, T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) is a promising new target for cancer immunotherapy. TIGIT is upregulated by immune cells, including activated T cells, natural killer cells, and regulatory T cells.

What is TIGIT a marker for?

Transcriptome Profiling Identifies TIGIT as a Marker of T-Cell Exhaustion in Liver Cancer. Hepatology.

What organs are affected by polio?

Polio is a viral disease which may affect the spinal cord causing muscle weakness and paralysis. The polio virus enters the body through the mouth, usually from hands contaminated with the stool of an infected person.

Is polio a virus or bacteria?

Polio is a viral disease which may affect the spinal cord causing muscle weakness and paralysis. The polio virus enters the body through the mouth, usually from hands contaminated with the stool of an infected person. Polio is more common in infants and young children and occurs under conditions of poor hygiene.

What kind of virus was polio?

Polioviruses are small single-stranded RNA viruses that belong to the Enterovirus subgroup of the family Picornaviridae. Humans are the only reservoir for polio virus.

What is the prognosis of CD155 cancer?

CD155 is barely or weakly expressed in various normal human tissues, but frequently overexpressed in human malignant tumors. CD155 overexpression promotes tumor cell invasion and migration, and is associated with tumor progression and poor prognosis.

What is the function of CD155?

CD155 is an immunoglobulin superfamily adhesion molecule involved in many different physiological processes ranging from cell adhesion and migration, proliferation and modulation of immune responses [1,2,3]. Based on its ability to mediate the binding of human poliovirus, CD155 was initially identified as PolioVirus Receptor (PVR) [4].

Is CD155 a negative regulator of adhesion signaling?

In line with these evidences, CD155 expression on glioma cells enhances cell dispersal both in vitro and in primary brain tissue by the disassembly of focal adhesions [31]. All together these findings implicate CD155 as a negative regulator of adhesion signaling and a promoter of an invasive phenotype.

Does the cd155/poliovirus receptor enhance the proliferation of Ras-mutated cells?

The CD155/poliovirus receptor enhances the proliferation of ras-mutated cells. Int. J. Cancer. 2008;122:317–324. doi: 10.1002/ijc.23080.