What is Dentinogenesis?

What is Dentinogenesis?

Dentinogenesis is the formation of dentin by odontoblasts of mesenchymal origin located at the periphery of the dental pulp (Figure 26.3). Dentinogenesis is initiated by the inductive influence of the enamel organ involving molecular signaling pathways, such as Wnt, Runx-2, and TGF-β.

Can dentinogenesis imperfecta be treated?

Dentinogenesis imperfecta may require a multidisciplinary approach involving restorative, prosthodontic, and orthodontic treatments. The options for pediatric dentist for dental treatment include a stainless steel crowns (SSC), a simple removable space maintainer appliance, and adhesive restoration.

Where does dentinogenesis begin?

Dentinogenesis is the formation of dentin, a substance that forms the majority of teeth. Dentinogenesis is performed by odontoblasts, which are a special type of biological cell on the outer wall of dental pulps, and it begins at the late bell stage of a tooth development.

What is Predentin?

[3] Predentin is the newly formed dentin before calcification and maturation. It is the innermost portion of dentin and is located adjacent to pulpal tissues. It is usually thick where active dentinogenesis occurs.

How do you fix dentinogenesis imperfecta?

What is the treatment for dentinogenesis imperfecta?

Dentinogenesis imperfecta treatment is generally focused first on the patient’s primary teeth. It includes restorative procedures, such as crowns or preventive fillings, to strengthen brittle teeth. Later in life, your dental professional may recommend dental implants or dentures as tooth replacement becomes necessary.

What causes Dentinogenesis imperfecta?

Dentinogenesis imperfecta can affect both primary (baby) teeth and permanent teeth. People with this condition may also have speech problems or teeth that are not placed correctly in the mouth. Dentinogenesis imperfecta is caused by genetic changes in the DSPP gene and is inherited in an autosomal dominant manner.

What is the difference between Predentin and dentin?

The innermost layer of dentin is known as predentin, and is the initial dentin matrix that is laid down prior to mineralization. It can be distinguished by its pale color when stained with haematoxylin and eosin. The presence of odontoblastic processes here allows the secretion of matrix components.

Is dentinogenesis imperfecta genetic?

What are the 3 types of dentin?

Dentine Types

• Primary dentine forms before tooth eruption.
• Secondary dentine forms after eruption, as the tooth develops with age.
• Reparative or tertiary dentine forms as a result of trauma to the odontoblasts; this can be thermal, chemical, bacterial or mechanical.

What do odontoblasts do?

Odontoblasts are specialized cells that produce dentin and exhibit unique morphological characteristics; i.e., they extend cytoplasmic processes into dentinal tubules.