What is Progeroid disease?

What is Progeroid disease?

Progeroid syndromes are a group of very rare genetic disorders that are characterized by clinical features that mimic physiological ageing, such as hair loss, short stature, skin tightness, cardiovascular diseases and osteoporosis.

What is Wiedemann Rautenstrauch Syndrome?

Wiedemann-Rautenstrauch syndrome (WRS), also known as neonatal progeroid syndrome, is a very rare genetic disorder characterized by an aged appearance at birth (old man look) growth delays before and after birth (prenatal and postnatal growth retardation), and deficiency or absence of the layer of fat under the skin ( …

What is segmental Progeroid syndrome?

HGPS and Werner syndrome (WS), also referred to as childhood- and adulthood-progeria respectively, are two of the best-characterized premature aging disorders; they are defined as segmental progeroid syndromes as multiple organs and tissues replicate phenotypes associated with physiological aging (Kudlow et al., 2007).

What is Marfanoid Progeroid lipodystrophy syndrome?

The marfanoid-progeroid-lipodystrophy syndrome (MFLS) is characterized by congenital lipodystrophy, premature birth with an accelerated linear growth disproportionate to weight gain, and progeroid appearance with distinct facial features, including proptosis, downslanting palpebral fissures, and retrognathia.

What are the disorders associated with accelerated aging?

Premature aging signs include, among others, alopecia, hair graying, lipodystrophy, osteoporosis, joint contractures, cataract, hearing loss, atherosclerosis, cardiovascular diseases, diabetes mellitus and malignancies at an early age.

How common is Marfanoid Progeroid lipodystrophy syndrome?

It is a genetic condition that is caused by mutations in the FBN1 gene, which encodes profibrillin, and affects the cleavage products of profibrillin, fibrillin-1, a fibrous structural protein, and asprosin, a glucogenic protein hormone. As of 2016, fewer than 10 cases of the condition have been reported.

What is lipodystrophy of the abdomen?

Lipodystrophy is a group of rare syndromes that cause a person to lose fat from some parts of the body, while gaining it in others, including on organs like the liver. A person can be born with lipodystrophy or develop it later in life.

Why am I aging so fast all of a sudden?

This is called extrinsic aging. As a result, premature aging can set in long before it was expected. In other words, your biological clock is more advanced than your chronological clock. Controllable factors such as stress, smoking and sun exposure can all play a role in expediting extrinsic aging.