What is seminoma in histology?

What is seminoma in histology?

Seminoma is the most common pure germ cell tumor (GCT) of the testis, accounting for up to 50% of cases. Among mixed GCTs, seminoma is also commonly present in combination with teratoma, yolk sac tumor, and/or embryonal carcinoma.

What is the difference between seminoma and non-seminoma?

Many testicular cancers are mixed germ cell tumors, meaning that they have both seminoma and non-seminoma cells. Only tumors that have 100 percent seminoma cells are considered seminomas, while non-seminomas contain different types of cells. Blood tests are one of the ways to determine the type of testicular tumor.

What is Seminomatous?

(SEH-mih-NOH-muh) A type of cancer that begins in germ cells in males. Germ cells are cells that form sperm in males or eggs in females. Seminomas occur most often in the testicle, but they may also occur in other areas of the body, such as the brain, chest, or abdomen. Seminomas tend to grow and spread slowly.

What are the differences between seminoma and Spermatocytic tumor?

Clinically, the main difference between spermatocytic and classical seminoma is the age of occurrence. Spermatocytic seminoma tends to occur more commonly, in men aged over 50, while in classical seminoma, the age at diagnosis is between 25 and 40 years.

What is Seminomatous tumor?

Seminoma is a malignant germ cell tumor that involves most commonly the testicle or less frequently the mediastinum, the retroperitoneum, or other extra-gonadal sites. It is one of the treatable and curable cancers, with a survival rate of over 95% if discovered in early stages.[1][2][3][4]

What are seminomas made of?

Microscopic examination shows that seminomas are usually composed of either a sheet-like or lobular pattern of cells with a fibrous stromal network. The fibrous septa almost always contain focal lymphocyte inclusions, and granulomas are sometimes seen.

Is non seminoma worse than seminoma?

More than 90% of cancers of the testicle start in cells known as germ cells. These are the cells that make sperm. The main types of germ cell tumors (GCTs) in the testicles are seminomas and non-seminomas. These types occur about equally.

What causes non seminoma?

These tumors are usually made up of more than one type of cancer cell. Although nonseminomas occur most often in the testicles or ovaries, they can occur in other tissues, such as the brain, chest, or abdomen. This happens when cells that have the ability to form sperm or eggs are found in other parts of the body.

What is the difference between seminoma and Nonseminomatous germ cell tumors?

Seminomas are very sensitive to radiation therapy. Nonseminoma: This more common type of testicular cancer tends to grow more quickly than seminomas. Nonseminoma tumors are often made up of more than one type of cell, and are identified according to these different cell types: Choriocarcinoma (rare)

What is a non Seminomatous germ cell tumor?

Summary. Nonseminomatous germ cell tumors are cancerous tumors commonly found in the pineal gland in the brain, in the mediastinum, or in the abdomen. They originate from cells that were meant to form sex cells (i.e., sperm or eggs).

What is difference between seminoma and Dysgerminoma?

Pathologically, dysgerminoma is the ovarian counterpart of the seminoma of the testis and the germinoma of extragonadal sites. Unlike seminomas of the testis, which are rare in the prepubertal period, dysgerminomas can occur at any age, although the peak incidence is 15 to 19 years.

How are seminomas diagnosed?

(The diagnosis is typically made via a biopsy.) If CIS is treated, it is with an orchiectomy (to remove the testicle) or with testicular radiation. If tumor marker levels are high, then the cancer is not stage 0, even when only CIS is found in the testicle, and there are no signs of cancer spread.

Are all seminomas malignant?

A seminoma is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations. It is a malignant neoplasm and is one of the most treatable and curable cancers, with a survival rate above 95% if discovered in early stages.

How fast does non seminoma grow?

The median lymph node growth rate for patients with seminoma was 1.35 mm/month (range 0.62-4.56) and for patients with non-seminoma 2.99 mm/month (range 0.77-7.06); the difference in growth rates was statistically significant (P=0.029).

Is non-seminoma worse than seminoma?

Are seminomas benign?

Is seminoma a Germinoma?

Malignant germ cell seminomatous tumors (germinomas) The name germinoma derives from the fact that they may occur also in females. Malignant seminomatous germ cell tumors occur more frequently between the ages of 20 and 40 years, and rarely in infancy.