What is sertindole used for?

What is sertindole used for?

Sertindole is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia. Sertindole improves negative symptoms, and is also effective for the treatment of neuroleptic-resistant schizophrenia.

What does amisulpride do to the brain?

Amisulpride is believed to work by blocking, or antagonizing, the dopamine D2 receptor, reducing its signalling. The effectiveness of amisulpride in treating dysthymia and the negative symptoms of schizophrenia is believed to stem from its blockade of the presynaptic dopamine D2 receptors.

What is the drug of choice for schizophrenia?

According to the American Psychiatric Association, second-generation (atypical) antipsychotics (SGAs)—with the exception of clozapine—are the agents of choice for first-line treatment of schizophrenia. Clozapine is not recommended because of its risk of agranulocytosis.

Is Blonanserin FDA approved?

Blonanserin has not been approved by the U.S. Food and Drug Administration. Poor adherence to antipsychotic medication is a consistent issue in managing schizophrenia, according to the authors.

Does sertindole cause weight gain?

Sertindole is associated with a low rate of extrapyramidal side effects, lacks sedative properties, and may induce a moderate weight gain.

Is amisulpride a safe drug?

Amisulpride demonstrated a satisfactory global safety profile in the range of doses usually prescribed. The number of patients having at least one extrapyramidal side-effect was higher in haloperidol patients compared with both amisulpride and risperidone patients (50% versus 30% in the two latter groups).

Is amisulpride a good drug?

Conclusions. In patients with schizophrenia, amisulpride reduces symptoms and dropouts relative to placebo and reduces need for antiparkinsonian drugs relative to conventional antipsychotics. In acutely ill patients, amisulpride is more effective and leads to fewer dropouts than conventional antipsychotics.

Does Blonanserin cause weight gain?

The mean weight gain with blonanserin at 4 weeks was 1.77 kg (3.46%) and at 8 weeks was 3.46 kg (6.75%) from the baseline.

What is Trihexyphenidyl used for?

Descriptions. Trihexyphenidyl is used alone or together with other medicines (e.g., levodopa) to treat Parkinson’s disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced.

What class of drug is Caplyta?

Caplyta is in a drug class* called atypical antipsychotics. Other drugs in this class that are used to treat some types or symptoms of bipolar disorder include: cariprazine (Vraylar) lurasidone (Latuda)

What does invega feel like?

INVEGA® can make some people feel dizzy, sleepy, or less alert. Until you know how you are going to respond to INVEGA®, be careful driving a car, operating machines, or doing things that require you to be alert. This medicine may make you more sensitive to heat.

How long can I take amisulpride?

Treatment with amisulpride is usually long-term unless you experience an adverse effect. Keep taking it unless your doctor tells you otherwise. Stopping amisulpride suddenly can cause problems so your doctor may want you to reduce your dose gradually if this becomes necessary.

What happens if you stop taking amisulpride?

Do not stop taking your medicine just because you feel better as your illness may get worse or come back. Unless your doctor tells you otherwise, amisulpride should not be stopped suddenly as this may cause withdrawal effects such as muscle stiffness or unusual body movements.

Does amisulpride cause memory loss?

Conclusion. This study suggests that a small dose of amisulpride improves the general psychopathology, working memory performance, and brain glucose metabolism of patients with schizophrenia treated with aripiprazole.

What type of drug is sertindole?

Sertindole (brand names: Serdolect and Serlect) is an antipsychotic medication. Sertindole was developed by the Danish pharmaceutical company Lundbeck and marketed under license by Abbott Labs. Like other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain.

When was sertindole approved in the EU?

In the European Union, sertindole was approved and marketed in 19 countries from 1996, but its marketing authorization was suspended by the European Medicines Agency in 1998 and the drug was withdrawn from the market.

Does sertindole increase the QTc interval?

Lundbeck cites the results of the Sertindole Cohort Prospective (SCoP) study of 10,000 patients to support its claim that although sertindole does increase the QTc interval, this is not associated with increased rates of cardiac arrhythmias, and that patients on sertindole had the same overall mortality rate as those on risperidone.

What is the history of schizophrenia in the Eastern Bloc?

From the 1960s until 1989, psychiatrists in the USSR and Eastern Bloc diagnosed thousands of people with sluggish schizophrenia, [297] [298] [299] based on “the assumption that symptoms would later appear,” [300] because the removal of legal rights from disabled people made it a convenient way to confine political dissidents. [301]