Which anesthesia is contraindicated in pregnancy?
Table of Contents
Which anesthesia is contraindicated in pregnancy?
Anaesthetic drugs and teratogenicity
| Drugs . | Side-effects and anaesthetic implications . |
|---|---|
| Non-steroidal anti-inflammatory drugs | Premature ductus arteriosus closure, avoid after 28 weeks; ketorolac contraindicated |
| Anticoagulants | |
| Warfarin | Teratogenic, crosses the placenta |
| Heparin | Does not cross the placenta |
Is isoflurane safe for pregnancy?
Isoflurane Pregnancy and Breastfeeding Warnings This drug should be used during pregnancy only if the benefit outweighs the risk. US FDA pregnancy category: Not assigned.
What is Category ABC in pregnancy?
In 1979, the FDA established five letter risk categories – A, B, C, D or X – to indicate the potential of a drug to cause birth defects if used during pregnancy. The categories were determined by assessing the reliability of documentation and the risk to benefit ratio.
Is sevoflurane safe during pregnancy?
Maternal sevoflurane exposure during pregnancy is associated with increased risk for behavioral deficits in offspring.
How does isoflurane affect pregnancy?
Inhalation of isoflurane at 1.3% during pregnancy has no significant influence on learning and memory of the offspring; exposure to isoflurane at 2.0% causes damage to spatial memory associated with inhibition of CREB phosphorylation in the granular cell layer of hippocampus dentate gyrus.
Is Articaine safe during pregnancy?
Articaine should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Articaine should be given to a pregnant woman only if clearly needed.
Can propofol be used in pregnancy?
Abstract. Propofol has been used for the induction and maintenance of general anesthesia during pregnancy although this is not an indication approved by Zeneca Pharmaceuticals. Compared with thiopentone, propofol reduces the cardiovascular response to laryngoscopy and tracheal intubation.
Does isoflurane cross the placental barrier?
However, in a similar animal model, exposure to high concentrations of isoflurane (3%) for only 1 hour caused significant neurodegeneration in fetal brain [2], suggesting a dose-dependent effect of isoflurane neurotoxicity. The majority of general anesthetics are lipophilic and can easily cross the placental barrier.
Does isoflurane cross the placenta?
Since anesthetics easily cross the placenta, the developing fetal brain will be exposed to inhaled anesthetics, such as isoflurane, when pregnant women require surgery.
Is it safe to work in the operating room when pregnant?
Copyright 2014 by the American Academy of Orthopaedic Surgeons. Pregnant or lactating staff working in the orthopaedic operating room may be at risk of occupational exposure to several hazards, including blood-borne pathogens, anesthetic gases, methylmethacrylate, physical stress, and radiation.
Does propofol cross the placenta?
Background: Propofol is an alternative to thiopental for induction of general anaesthesia for cesarean section. It crosses the placenta and induces vasodilatation of isolated vessels and may therefore alter fetal placental vascular resistance.
Why is articaine contraindicated in pregnancy?
Articaine / epinephrine Pregnancy Warnings Articaine-epinephrine has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of fetal death and an increase in fetal skeletal variations, but these effects may have been attributable to the severe maternal toxicity.
Is epinephrine inhaler safe during pregnancy?
Epinephrine Pregnancy Warnings. Use is considered acceptable during pregnancy; use with caution during labor and delivery; avoid use during the second stage of labor.
What pregnancy category is Propofol?
Discussion: Propofol is an intravenous anesthetic agent commonly used for the sedation of mechanically ventilated patients and is the only sedative agent that carries a pregnancy category B rating.
Is precedex safe in pregnancy?
In a study in the pregnant rat, placental transfer of dexmedetomidine was observed when radiolabeled dexmedetomidine was administered subcutaneously. Thus, fetal exposure should be expected in humans, and Precedex should be used during pregnancy only if the potential benefits justify the potential risk to the fetus.
Which anesthesia drugs cross the placenta?
Classes of drugs that are known to cross the placenta include opiates, benzodiazepines, ephedrine, local anesthetics, beta blockers, barbiturates, and propofol. Drugs that are known to cross the placenta but are generally considered safe include propofol, ketamine, and fentanyl.
