How do you prescribe Beriplex?
Table of Contents
How do you prescribe Beriplex?
Beriplex should be administered intravenously at no more than 3 units per kg per ml (maximum 210 units per ml). The maximum dose should not exceed 5000 IU of Factor IX. The recovery and duration of effect may vary, therefore should be monitored. Beriplex is a virally inactivated product.
How fast can you give Beriplex?
Beriplex® P/N should be administered intravenously at no more than 3 IU/kg/min (max 210 IU/min). A syringe driver should be used if available. The maximum single dose should NOT exceed 5000 IU factor XI. Primary measure of haemostatic efficacy is correction of INR.
How long does Beriplex last for?
The correction of the vitamin K antagonist-induced impairment of haemostasis is reached 30 minutes after the injection and will persist for approximately 6-8 hours.
What is Beriplex used for?
What is Beriplex used for? Beriplex is used for the prevention (during surgery) and treatment of bleedings caused by the acquired or congenital lack of vitamin K-dependent coagulation factors II, VII, IX and X in the blood, when purified specific coagulation factor products are not available.
Is Beriplex a PCC?
Beriplex® (PCC) is a blood product and should not be mixed with any other drug, diluent or solution.
When do you give prothrombin complex?
The FDA-approved indication is for urgent reversal of acquired coagulation factor deficiency induced by warfarin-induced anticoagulation in patients presenting with major acute bleeding (intracerebral hemorrhage-ICH) or needing urgent invasive surgery or procedure.
How long does vitamin K take to reverse warfarin?
PCC will reverse anticoagulation within minutes of administration; FFP administration can take hours due to the volume required; vitamin K effect takes 12 to 24 hours, but administration of vitamin K is needed to counteract the long half-life of warfarin.
How is Beriplex stored?
Beriplex is stable at temperatures between 0 and 25C and should be stored in a fridge in the emergency department. If Beriplex is used then the attached form should be completed and returned to Blood Transfusion to allow re-stocking of the Emergency Department supply.
What is in 4-factor PCC?
The 4-factor prothrombin complex concentrate (4F-PCC), which contains the human coagulation factors II, VII, IX and X together with the endogenous inhibitor proteins S and C, is indicated for the urgent reversal of acquired coagulation factor deficiency induced by VKA (e.g. warfarin or coumarin) therapy in adult …
When can I check INR after PCC?
1. Give 4F PCC* 1500 to 2000 units¶ IV over 10 minutes. Check INR 15 minutes after completion of the infusion. If INR is not ≤1.5, give additional 4F PCC (refer to topic or drug reference for details).
Can you overdose on vitamin K?
Vitamin K is a fat-soluble nutrient that’s important for blood clotting, healthy bones and other bodily functions. It’s rare that you’ll overdose on vitamin K by eating things like broccoli. But in supplement form, it can induce blood clots, which can lead to heart attacks and strokes, if you take too much.
What is PCC vs FFP?
FFP is the standard of care in the United States ; however, FFP needs to be given in a dose of 15-20 mL/kg and therefore requires a large-volume infusion. PCC contains high levels of vitamin K-dependent cofactors and thus involves a smaller-volume infusion than FFP and more rapid administration.
What is PCC and Octaplex?
DESCRIPTION OF PRODUCT: ▪ octaplex ® is a manufactured prothrombin complex concentrate (PCC) that is derived from human. plasma. ▪ Manufacturing process includes solvent/detergent viral inactivation and a nanofiltration step.
How is PCC dosed?
Dosing of PCC Although questions persist regarding the minimum effective dose and the maximum safe dose, the average dose recommended for reversal of supratherapeutic INR is 25– 50 units/kg, based upon the factor IX component. Each of the PCC formulations contain varying amounts of factors II, VII, IX, and X.
What is the INR of PCC?
The INR values remained stable 60 min and 12-24 h after the PCC administration. The 500 IU of PCC is likely to be optimal dose of PCC for emergent reversal of INR in patients requiring rapid correction of INR below 5.0, but to be inadequate dose in patients with INR of 5.0 or more.
How much vitamin K can you take a day?
The AI amount is estimated to ensure nutritional adequacy. For adults 19 years and older, the AI for vitamin K is 120 micrograms (mcg) daily for men and 90 mcg for women and for those who are pregnant or lactating.
How much vitamin K do I need a day?
Adults need approximately 1 microgram a day of vitamin K for each kilogram of their body weight. For example, someone who weighs 65kg would need 65 micrograms a day of vitamin K, while a person who weighs 75kg would need 75 micrograms a day. A microgram is 1,000 times smaller than a milligram (mg).
