Is tamoxifen liver toxic?

Is tamoxifen liver toxic?

Hepatotoxicity. Tamoxifen has been associated with rare instances of idiosyncratic, clinically apparent liver injury, typically arising within the first six months of treatment and having variable presentations with cholestatic, mixed or hepatocellular pattern of enzyme elevations.

What is the most severe adverse effect of tamoxifen?

The most serious health risks of tamoxifen, such as endometrial cancer (cancer of the lining of the uterus) and blood clots in the lungs, are rare [102].

Do different brands of tamoxifen have different side effects?

We have seen good anecdotal evidence that the side effects and tolerance of tamoxifen varies with brand type. A small series of patients have reported differing symptoms with alternative brands that ceased on stopping and recurred on restarting individual preparations.

What can you take instead of tamoxifen?

Arimidex (chemical name: anastrozole) Aromasin (chemical name: exemestane) Femara (chemical name: letrozole)

Is it OK to drink wine while taking tamoxifen?

Alcohol can raise the risk of side effects with tamoxifen, some of which can be serious. Alcohol makes it harder for tamoxifen to work properly and should be limited or avoided while you’re taking this medication. Alcohol can raise your risk of developing breast cancer.

Do tamoxifen side effects get worse over time?

Women who expect to have more and more severe side effects before hormonal therapy starts do have worse side effects after 2 years of treatment.

What happens if I don’t take my tamoxifen?

Postmenopausal women diagnosed with hormone-receptor-positive disease are 35% to 61% more likely to have breast cancer come back if they don’t take hormonal therapy as prescribed.

What foods should not be eaten when taking tamoxifen?

Is there anything that I should avoid eating or drinking while on Tamoxifen?

• Grapefruit. Grapefruit and grapefruit juice are well-known disruptors of numerous medications 2.
• Turmeric/ Curcumin.
• Black cohosh.
• St.
• St.
• Ginseng.
• Chamomile.
• Soya.

Does tamoxifen cause facial hair growth?

The relatively rapid onset of hirsutism—the pattern of coarse hairs in androgenic distribution—following the administration of tamoxifen and the exclusion of other possible causes with normal hormonal assay, strongly suggests a causal relationship with the drug.

Can tamoxifen cause facial hair?