What does OTf mean in chemistry?

What does OTf mean in chemistry?

Illustrated Glossary of Organic Chemistry – Triflate (trifluoromethanesulfonate; TfO) Trifluoromethanesulfonate (triflate; TfO; OTf): An ester or salt of trifluoromethanesulfonic acid (CF3SO3H).

What is triflic acid used for?

Triflic acid belongs to the class of superacids, it is the strongest Bronstedt acid available at industrial scale. It is used as an acidic catalyst in many organic synthesis reactions(alkylation, esterification, etherification, acylation, isomerization, ethoxylation, cyclization, cationic rearrangement, etc .)

Is OTf electron withdrawing?

The trifluoromethanesulfonyl group (OTf) is one of the strongest electron-withdrawing groups and thus, the Ln(OTf)3 compounds are expected to be stronger Lewis acids compared to LnCl3 or LnBr3.

What is TMS in organic chemistry?

A trimethylsilyl group (abbreviated TMS) is a functional group in organic chemistry. This group consists of three methyl groups bonded to a silicon atom [−Si(CH3)3], which is in turn bonded to the rest of a molecule.

Why is triflic acid so strong?

Its extreme acidity can be derived from the extreme amount of resonance between the sulfur and three oxygen atoms coupled with the extremely electron-withdrawing qualities of the fluorocarbon group. Triflic acid is also very effective because its conjugate base does not act as a nucleophile.

How do you make triflic acid?

Trifluoromethanesulfonic acid is produced industrially by electrochemical fluorination (ECF) of methanesulfonic acid: CH3SO3H + 4 HF → CF3SO2F + H2O + 3 H. The resulting CF3SO2F is hydrolyzed, and the resulting triflate salt is reprotonated.

Is OTF a good leaving group?

A triflate group is an excellent leaving group used in certain organic reactions such as nucleophilic substitution, Suzuki couplings and Heck reactions.

What is OTs Group?

OTs in organic chemistry stands for tosylate. It is a functional group which is formed by the loss of the hydrogen of OH in para-toluenesulfonic… See full answer below.

Is OTS a better leaving group than Cl?

Good leaving groups are weak bases. They’re happy and stable on their own. Some examples of weak bases: halide ions (I-, Br-, Cl-) water (OH2), and sulfonates such as p-toluenesulfonate (OTs) and methanesulfonate (OMs). The weaker the base, the better the leaving group.

Why is TMS used?

Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression. TMS is typically used when other depression treatments haven’t been effective.

Why is TMS used as standard?

Tetramethylsilane became the established internal reference compound for 1H NMR because it has a strong, sharp resonance line from its 12 protons, with a chemical shift at low resonance frequency relative to almost all other 1H resonances. Thus, addition of TMS usually does not interfere with other resonances.

Is triflic acid a Lewis acid?

Triflic acid, the short name for trifluoromethanesulfonic acid, TFMS, TFSA, HOTf or TfOH, is a sulfonic acid with the chemical formula CF3SO3H. It is one of the strongest known acids. Triflic acid is mainly used in research as a catalyst for esterification….Triflic acid.

Is triflic acid corrosive?

* Trifluoroacetic Acid is a CORROSIVE CHEMICAL and contact can severely irritate and burn the skin and eyes with possible eye damage.

What is TsCl in organic chemistry?

This white, malodorous solid is a reagent widely used in organic synthesis. Abbreviated TsCl or TosCl, it is a derivative of toluene and contains a sulfonyl chloride (−SO2Cl) functional group.

Is OTs a weak base?

Some examples of weak bases: halide ions (I-, Br-, Cl-) water (OH2), and sulfonates such as p-toluenesulfonate (OTs) and methanesulfonate (OMs). The weaker the base, the better the leaving group.