What drugs should not be taken with simvastatin?

What drugs should not be taken with simvastatin?

Do not use simvastatin if you are also taking boceprevir (Victrelis®), cobicistat-containing products (Stribild®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), danazol (Danocrine®), gemfibrozil (Lopid®), nefazodone (Serzone®), telaprevir (Incivek®), certain antibiotics (eg, clarithromycin, daptomycin, erythromycin.

Has simvastatin been taken off the market?

There is no complete Simvastatin Recall from the market. However, due to FDA warnings, there are strict restrictions on the drug, especially the 80mg dose. In 2011, the FDA announced changes for the safety labels of Simvastatin, because of increased risk of injury while taking the highest dose of 80 milligrams.

What are the side effects of simvastatin Ezetimibe?

Common side effects of ezetimibe and simvastatin may include:

• headache;
• muscle pain;
• abnormal liver function tests;
• diarrhea; or.
• cold symptoms such as stuffy nose, sneezing, sore throat.

Why is simvastatin combined with ezetimibe?

Ezetimibe and simvastatin combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels.

Is simvastatin a high risk medication?

[06-08-2011] The U.S. Food and Drug Administration (FDA) is recommending limiting the use of the highest approved dose of the cholesterol-lowering medication, simvastatin (80 mg) because of increased risk of muscle damage.

Is simvastatin a good drug?

Simvastatin is used together with a proper diet to treat high cholesterol and triglyceride (fat) levels in the blood. This medicine may help prevent medical problems (eg, heart or blood vessel problems, heart attacks, or strokes) caused by clogged blood vessels.

When is the best time to take ezetimibe simvastatin?

Official answer. There is no specific time of the day that is best to take ezetimibe, as it works exactly the same whether you take in the morning, afternoon or at night. Ezetimibe is taken once a day, at the same time each day and it can be taken with or without food.

Which is better ezetimibe or statins?

Ezetimibe lowers low-density lipoprotein cholesterol (LDL-C) by 15-20% when used alone2 as compared to 5-10% from doubling the dose of statin. A recent pooled analysis3 of 17 double-blind trials of patients who were already on a statin showed that the largest percent reductions in LDL-C were seen with adding ezetimibe.

What is best cholesterol medicine?

Statins — Statins are one of the best-studied classes of medications and the most commonly used drugs for lowering LDL cholesterol. They are the most effective drugs for prevention of coronary heart disease, heart attack, stroke, and death.

What is the disadvantage of taking simvastatin?

While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people who take them and may rarely cause liver damage.

What do simvastatin 20 mg tablets look like?

Simvastatin Tablets, USP 20 mg are orange to dark orange, oval, biconvex, film-coated tablets with the logo “B302” debossed on one side and “20” on the other side. They are supplied as follows:

How does simvastatin affect p21 upregulation?

Simvastatin also promoted AMP-activated protein kinase (AMPK) activation, which induced p21 upregulation by increasing its transcription. Consistent with this finding, we found genetic silencing of AMPK reduced p21 expression; however, AMPK silencing had no effect on p27 expression in HCC cells.

How effective is topical simvastatin-cholesterol for disseminated superficial actinic porokeratosis?

Topical simvastatin-cholesterol for disseminated superficial actinic porokeratosis: An open-label, split-body clinical trial Topical simvastatin-cholesterol cream improved lesion number, erythema and scale on treated limbs compared with controls. Patient-reported disease activity also improved.

How does simvastatin prevent proteasomal degradation?

Simvastatin decreased Skp2 expression at the transcriptional level, which resulted in p27 accumulation by preventing proteasomal degradation, an effect mediated by signal transducer and activator of transcription 3 (STAT3) inhibition.