What is Colchicum used for?

What is Colchicum used for?

Colchicine is an alkaloid and is used medicinally as a gout suppressant, in the treatment of Familial Mediterranean Fever, in veterinary science as an antineoplastic, and in genetic research.

What is the common name of Colchicum?

autumn crocus
Colchicum autumnale, commonly called autumn crocus or meadow saffron, is a cormous perennial that typically blooms in early fall.

Why Colchicum is called Naked Lady?

The name “naked ladies” is because the flowers emerge from the ground long before the leaves appear. Despite the vernacular name of “meadow saffron”, this plant is not the source of saffron, which is obtained from the saffron crocus, Crocus sativus – and that plant, too, is sometimes called “autumn crocus”.

Is colchicine and Colchicum same?

Colchicine is an alkaloid derived from two plants of the lily family, Colchicum autumnale and Gloriosa superba, that was first recommended for the treatment of gout in the sixth century A.D.7 It remains widely in use today for the treatment of acute gout.

Where is Colchicum found?

It is a member of the botanical family Colchicaceae, and is native to West Asia, Europe, parts of the Mediterranean coast, down the East African coast to South Africa and the Western Cape. In this genus, the ovary of the flower is underground….

Does saffron contain colchicine?

Introduction: Colchicum autumnale, commonly known as the autumn crocus or meadow saffron, contains the antimitotic colchicine, which binds to tubulin and prevents it forming microtubules that are part of the cytoskeleton in all cells.

Which part of Indian Colchicum is used as drug?

Plants in this genus contain toxic amounts of the alkaloid colchicine which is used pharmaceutically to treat gout and Familial Mediterranean fever. The use of the roots and seeds in traditional medicine is thought to have arisen due to the presence of this drug. Its leaves, corm and seeds are poisonous.

Is colchicine a high risk medication?

Colchicine is a plant-based alkaloid, extracted from Colchicum autumnale (autumn crocus, meadow saffron) and Gloriosa superba (glory lily) used to treat gout and some other inflammatory conditions. It is considered a high-risk medicine because it is associated with significant toxicity when not used correctly.

What is a substitute for colchicine?

ColciGel® is a first line agent in the treatment of acute gout flares and an alternative to oral colchicine in those patients who experience either adverse drug effects (ADRs) or who do not achieve suitable symptom relief.

What is colchicine made from?

What plant is colchicine from?

Colchicine is one of the oldest remedies still in use today. It is derived from the bulb-like corms of the Colchicum autumnale plant, also known as autumn crocus. Its history as an herbal remedy for joint pain goes back at least to the 1500 BCE Egyptian manuscript, the Ebers Papyrus (Figure 1).

Is there a natural colchicine?

A naturally occurring plant alkaloid, colchicine primarily is found in Colchicum species, especially C. autumnale L. (Liliaceae), the autumn crocus or meadow saffron from the Mediterranean (quite different from common culinary saffron, Crocus sativa L., which is from another plant family, Iridaceae).

Who should not take colchicine?

Colchicine should ideally be avoided, or used with caution, in frail patients, those who weigh < 50 kg, or patients with hepatic or renal impairment (eGFR 10–50 mL/min/1.73m2). Colchicine is contraindicated in patients with an eGFR <10 mL/min/1.73m2.

What is a natural colchicine?

What is a natural alternative to colchicine?

The reasons for considering whole herbs versus only isolated constituents in the context of Colchicum and colchicine are highlighted. Three herbal foods that are helpful for gout are then discussed: Apium graveolens (celery); Prunus avium (sweet cherry) and P. cerasus (tart cherry); and Coffea arabica (coffee).