What is GOG clinical trials?
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What is GOG clinical trials?
We conduct clinical and translational research that positively impacts patients through the prevention and treatment of gynecologic malignancies, including cancers that arise from the ovaries, uterus, cervix, vagina, and vulva.
Is GOG part of NRG?
The Gynecologic Oncology Group (GOG), now part of the NRG Oncology network since the re-alignment of the National Clinical Trials Network in 2014, has played a fundamental role in creating the standard of care for women with ovarian cancer.
What is Gog medical?
Gynecologic Oncology Group + 3. Oncology, Pathology, Health. Oncology, Pathology, Health.
What is Zn c3?
ZN-c3 is a potentially first-in-class and best-in-class oral inhibitor of Wee1 in development for the treatment of advanced solid tumors.
When was NRG Oncology formed?
2014
In 2014, in response to NCI’s consolidation of its cooperative group research into the National Clinical Trials Network (NCTN) Program, the Radiation Therapy Oncology Group joined together with two other national cancer cooperative groups, the Gynecologic Oncology Group (GOG), and the National Surgical Breast and Bowel …
What does RTOG stand for?
“The Radiation Therapy Oncology Group (RTOG) was initially organized in 1968 under the direction of Dr. Simon Kramer as a national cooperative group for the purpose of conducting radiation therapy research and clinical investigations. Funding from the National Cancer Institute (NCI) began in 1971.
Is Swog part of alliance?
The Alliance is a new National Cancer Institute (NCI)-sponsored cancer cooperative group, joining three other groups including the cancer research group known as ECOG-ACRIN (the American College of Radiology Imagining Network and the Eastern Cooperative Oncology Group), NRG (formerly National Surgical Bowel and Bladder …
Is WEE1 a phosphatase?
Wee1 is a kinase that delays mitosis via inhibitory phosphorylation of Cdk1, while Cdc25 is a phosphatase that promotes mitosis by removing the inhibitory phosphorylation. Although Wee1 and Cdc25 are conserved proteins, it has remained unclear whether their functions and regulation are conserved across diverse species.
What is Plk1 gene?
Plk1 is a serine/threonine protein kinase that plays multiple critical roles in centrosome maturation, mitotic chromosome segregation, cytokinesis, and the DNA damage response.
How does Apr 246 work?
In addition to targeting mutant p53, APR-246 inhibits the selenoprotein thioredoxin reductase 1 (TrxR1) and converts it to an active oxidase19, and depletes cellular gluthatione (GSH)20,21,22. This induces reactive oxygen species (ROS) and presumably contributes to the anticancer effect of APR-24623.
What phosphorylates WEE1?
Wee1 was shown to phosphorylate histone H2B at tyrosine 37 residue which regulated global expression of histones.
What does NRG oncology stand for?
As a response to the reconstitution of the NCI-supported cooperative cancer groups, the NSABP, RTOG, and GOG elected to join forces to create a new NCTN group now known as NRG Oncology (acronym NRG derived from names of parental groups).
What is SWOG trial?
Along with being publicly funded, SWOG trials seek to improve medical care across the cancer continuum – prevention, treatment, care delivery, symptom control and quality of life, survivorship, and palliative and end-of-life care.
What does SWOG stand for?
That’s how we got our original name – the Southwest Cancer Chemotherapy Study Group, which later become the Southwest Oncology Group, which was shortened to SWOG, then changed to SWOG Cancer Research Network in 2018.
What is wee phenotype?
Deficiency in wee1 causes premature mitotic entry, resulting in small size in yeast (hence the “wee” phenotype).
Is APR 246 FDA approved?
Aprea Therapeutics Receives FDA Breakthrough Therapy Designation for APR-246 in Combination with Azacitidine for the Treatment of Myelodysplastic Syndromes (MDS) with a TP53 Mutation. BOSTON , Jan. 30, 2020 (GLOBE NEWSWIRE) — Aprea Therapeutics, Inc.
