What is ICG fluorescence?

What is ICG fluorescence?

ICG is a tricarbocyanine dye which fluoresces, i.e. emits light, after excitation under near-infrared light at 806 nm light. ICG is highly soluble in water and binds to β-lipoproteins, particularly to albumin. Because of the high protein content of lymph, ICG accumulates in the lymphatic pathways and lymph nodes.

Is indocyanine green a contrast?

Nanoparticles 100 nm in diameter containing indocyanine green (ICG) have been developed as a contrast agent for photoacoustic (PA) imaging based on (photonic explorers for biomedical use by biologically localized embedding PEBBLE) technology using organically modified silicate (ormosil) as a matrix.

What does indocyanine green bind to?

Assessment of hepatic function Indocyanine green (ICG) clearance is the quantitative measure of hepatic function most used worldwide. ICG is a water-soluble tricarbocyanine dye that binds to albumin and distributes rapidly and uniformly in the blood after intravenous injection.

How long does indocyanine green work?

Because of the plasma protein binding, ICG stays for up to 20 to 30 minutes in the vessels (intravasally). When the eye is examined, it thus stays for a long time in tissues with a higher blood flow, such as the choroid and the blood vessels of the retina.

What is indocyanine green made of?

Indocyanine Green Description Indocyanine Green for injection USP is a sterile, lyophilized green powder containing 25 mg of Indocyanine Green with no more than 5% sodium iodide. It is packaged with Sterile Water for injection, USP used to dissolve the Indocyanine Green.

What is Indocyanine Green made of?

Does Indocyanine Green contain iodine?

Because indocyanine green contains iodine, the iodine-binding capacity of thyroid tissue may be reduced for at least 1 week after indocyanine green administration. Do not perform radioactive iodine uptake studies for at least 1 week after the administration of indocyanine green.

Does indocyanine green contain iodine?

Is there iodine in ICG?

ICG contains sodium iodide and, according to the manufacturer, it should be used with caution in patients who have a history of allergy to iodides because of the risk of anaphylaxis.

Is Indocyanine Green nephrotoxic?

The most widely adopted reagent for NIRF in urologic surgery is the fluorescent dye, indocyanine green (ICG). ICG is non-nephrotoxic, excreted exclusively by the liver, with inci- dences of minor and major complications being exceedingly rare [1].