What is NS1 protein in dengue?

What is NS1 protein in dengue?

NS1 is a key viral protein that is required for both DENV replication and dengue disease pathogenesis. The NS1 protein comprises of 352 amino acid residues that share approximately 70% sequence similarity among all four DENV serotypes and 40–50% sequence similarity to other flaviviruses9,10.

Which 3 viruses are members of the Flavivirus?

Flaviviridae

• Arenaviruses.
• Bunyavirales.
• Filoviruses.
• Flaviviruses.

Is Je a Flavivirus?

Japanese encephalitis (JE) virus, a flavivirus, is closely related to West Nile and St. Louis encephalitis viruses. JE virus is transmitted to humans through the bite of infected Culex species mosquitoes, particularly Culex tritaeniorhynchus.

Why is the NS1 protein important?

The viral genome replication process within the host cell is mainly driven by the NS proteins. The NS1 protein acts as a scaffolding protein that anchors the replication complex to the endoplasmic reticulum (ER) membrane and interacts physically with NS4B (4).

Is NS1 antigen specific for dengue?

NS1 Ag assay is useful, sensitive and specific for the diagnosis of dengue infection, especially during the acute phase when antibodies are not detectable and the dengue serology was negative. Early diagnosis and timely intervention can reduce the mortality due to severe dengue infection.

What is serotype of dengue?

Dengue is caused by a virus of the Flaviviridae family and there are four distinct, but closely related, serotypes of the virus that cause dengue (DENV-1, DENV-2, DENV-3 and DENV-4). Recovery from infection is believed to provide lifelong immunity against that serotype.

What is the name of the disease that is caused by Flavivirus?

Flaviviruses are named for the yellow fever virus; the word flavus means ‘yellow’ in Latin, and yellow fever in turn is named from its propensity to cause yellow jaundice in victims….

Is Ebola a Flavivirus?

Flaviviruses, including Zika and Dengue viruses, and Filoviruses, including Ebola and Marburg viruses, are significant global public health threats.

Is Ebola a flavivirus?

Is Zika a flavivirus?

Zika virus disease is caused by a virus from the Flavivirus genus, Flaviviridae family, from the Spondweni group. It was first isolated in 1947 from a monkey in the Zika forest, Uganda, then in mosquitoes (Aedes africanus) in the same forest in 1948, and in a human in Nigeria in 1952.

What does NS1 do in influenza?

The NS1 of influenza A virus is a 26,000 Dalton protein. It prevents polyadenylation of cellular mRNAs to circumvent antiviral responses of the host, e.g., maturation and translation of interferon mRNAs. NS1 might also inhibit splicing of pre-mRNA by binding to a stem-bulge region in U6 small nuclear RNA (snRNA).

What is NS1 positive?

A positive NS1 test result confirms dengue virus infection without providing serotype information. A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.

What are the symptoms of flavivirus?

What are the symptoms of Flaviviridae? General symptoms include fever, body aches, headache, and joint pain. Some of these illness may also cause vomiting and diarrhea. The diseases caused by Flaviviridae viruses can be fatal.

How does flavivirus cause dengue?

The transmission cycle starts with an adult female Aedes feeding on a dengue infected person. The virus then develops within the mosquito in approximately seven days (shorter in warm weather, longer in cooler weather). Once the mosquito has become infective, it transmits the virus when biting a subsequent human.

Is Zika a Flavivirus?

Is dengue a Flavivirus?

Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus includes other arthropod borne viruses such as yellow fever virus, West Nile virus, Zika virus, tick-borne encephalitis virus.