What is the mechanism of action of nicardipine?

What is the mechanism of action of nicardipine?

Mechanism Of Action Nicardipine inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations.

What is nicardipine hydrochloride used for?

Nicardipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries.

What type of calcium channel blocker is nicardipine?

Nicardipine (Cardene) is a medication used to treat high blood pressure and angina. It belongs to the dihydropyridine class of calcium channel blockers. It is also used for Raynaud’s phenomenon.

Is nicardipine a non dihydropyridine?

Nicardipine is a dihydropyridine-type calcium channel blocker (CCB) with a peculiar cerebrovascular profile developed approximately 30 years ago.

How is nicardipine metabolized?

Nicardipine HCl is metabolized extensively by the liver. Nicardipine has been shown to be rapidly and extensively metabolized by the liver.

What drug category is nicardipine?

Nicardipine is in a class of medications called calcium channel blockers. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard.

What is the classification of nicardipine?

Nicardipine is in a class of medications called calcium channel blockers. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. It controls chest pain by increasing the supply of blood and oxygen to the heart.

How does calcium channel blockers work?

Calcium channel blockers are medications used to lower blood pressure. They work by preventing calcium from entering the cells of the heart and arteries. Calcium causes the heart and arteries to squeeze (contract) more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open.

What is the difference between a dihydropyridine and non dihydropyridine calcium channel blocker?

The dihydropyridines are more vascular selective and the non-dihydropyridines are more myocardial selective and tend to reduce the heart rate. Further important differences are between short- and long-acting forms of the calcium channel antagonists.

How does a thiazide diuretic work?

Thiazide diuretics work by blocking sodium and chloride (Na/Cl) channels in the distal convoluted tubule of the nephron and inhibit the reabsorption of sodium and water.

Where is cardene metabolized?

Because CARDENE is extensively metabolized by the liver, the plasma levels of the drug are influenced by changes in hepatic function.

Is nicardipine a vasopressor?

Position the patient so as to avoid cerebral anoxia. Use vasopressors for patients exhibiting profound hypotension. Cardene (nicardipine hydrochloride) is a calcium ion influx inhibitor (slow channel blocker or calcium channel blocker).

How do dihydropyridine calcium channel blockers work?

How do dihydropyridines work? Dihydropyridines work by binding to and blocking voltage-gated L-type calcium channels found on smooth muscle cells of arterial blood vessels. Usually, these channels open in response to an electrical signal, or action potential, hence the name “voltage-gated” L-type calcium channels.

Which type of calcium channel is inhibited by dihydropyridines?

The results reported in this paper indicate that current flow through voltage-dependent L-type Ca channels in DRG neurons is inhibited by the antagonist DHP nifedipine. Furthermore, the action of this Ca channel antagonist was found to be voltage-dependent.

What are the non-dihydropyridine calcium channel blockers?

Non-dihydropyridines — The non-dihydropyridines, including verapamil and diltiazem, are used in the management of hypertension, chronic stable angina, cardiac arrhythmias, or for proteinuria reduction.

What is the mechanism of calcium channel blockers?