What is the pathogenesis of myocardial infarction?
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What is the pathogenesis of myocardial infarction?
Myocardial Infarction (MI) The pathogenesis can include: Occlusive intracoronary thrombus – a thrombus overlying an atheromatous plaque is estimated to cause 75% of myocardial infarctions, with superficial plaque erosion present in the remaining 25%.
What is the pathogenesis of Ischaemic heart disease?
According to the conventional IHD pathophysiological point of view, an obstructive plaque that inhibits blood flow, through the coronary artery, triggers myocardial ischemia.
What are the troponin levels?
For example, the normal range for troponin I is between 0 and 0.04 ng/mL but for high-sensitivity cardiac troponin (hs-cTn) normal values are below 14ng/L. Other types of heart injury may cause a rise in troponin levels.
What are the three zones of injury of myocardial infarction?
The post-infarct heart is characterized by three distinct regions, including the remote (“normal”) myocardium, the dense infarcted scar, and the border zone (BZ) transition region between remote and infarcted myocardium.
What is the pathogenesis of atherosclerosis?
Atherosclerosis is a disease of large and medium-sized arteries, characterized by endothelial dysfunction, vascular inflammation and the accumulation of modified lipid, inflammatory cells and cell debris in ‘plaques’ within the vascular wall.
What is the Pathophysiology of ischemic stroke?
Pathophysiology of Stroke Ischemic stroke is caused by deficient blood and oxygen supply to the brain; hemorrhagic stroke is caused by bleeding or leaky blood vessels. Ischemic occlusions contribute to around 85% of casualties in stroke patients, with the remainder due to intracerebral bleeding.
What is troponin used for?
A troponin test measures the levels of troponin T or troponin I proteins in the blood. These proteins are released when the heart muscle has been damaged, such as occurs with a heart attack.
What is the difference between troponin and CK MB?
The main difference between CK-MB and troponin is that CK-MB only stays elevated 1-2 days while troponin stays elevated for 1-2 weeks. Therefore, CK-MB is the best test to detect a reinfarction a few days after the initial infarction.
Which type of cell injury occurs in myocardial infarction?
During myocardial infarction, cardiac myocytes in the ischemic zone die by both apoptosis and necrosis.
What is the first event that occurs in the pathogenesis of atherosclerosis?
Hypercholesterolaemia is considered one of the main triggers of atherosclerosis. The increase in plasma cholesterol levels results in changes of the arterial endothelial permeability that allow the migration of lipids, especially LDL-C particles, into the arterial wall.
