What was Theralizumab used for?
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What was Theralizumab used for?
TheraMAB LLC is developing theralizumab, a first-in-class humanised IgG4 monoclonal antibody, for the treatment of autoimmune disorders, including plaque psoriasis and systemic lupus erythematosus, and solid tumours.
Why did TGN1412 fail?
It is likely that activation of CD4+ effector memory T-cells by TGN1412 was responsible for the cytokine storm. Lack of CD28 expression on the CD4+ effector memory T-cells of species used for pre-clinical safety testing of TGN1412 offers an explanation for the failure to predict a ‘cytokine storm’ in humans.
Which medication has a side effect of cytokine release syndrome?
CRS can be triggered by infections or be associated with drugs such as monoclonal antibodies (e.g., rituximab), conventional chemotherapy, and immunotherapies with chimeric antigen receptor T (CAR T) cells (Shimabukuro-Vornhagen et al., 2018).
Why are monoclonal antibodies not widely used?
So far, they are not widely used because they must be given early in infection and infused in a hospital or clinic.
What did Tegenero trial TGN1412 lead to?
In a 2006 Phase I study, TGN1412, an agonist mAb targeting CD-28, was administered to healthy volunteers and resulted in cytokine storm, an adverse event that is often fatal [36].
What did TeGenero trial TGN1412 lead to?
How does cytokine storm feel?
Cytokine release syndrome (CRS) happens when your immune system responds to infection or immunotherapy drugs more aggressively than it should. CRS symptoms include fever, nausea, fatigue and body aches. Prompt treatment is essential, as symptoms can worsen quickly.
What happened to Ryan in the TGN1412 trial?
Six healthy young men suffered organ failure after taking the drug TGN1412 at Northwick Park hospital in London. The worst-affected, plumber Ryan Wilson, who lost toes and fingers, was awarded £2m compensation, as the Daily Mail reported at the time.
