How is nemaline myopathy treated?

How is nemaline myopathy treated?

No specific treatment exists for nemaline myopathy. Treatment is supportive and directed toward the specific symptoms that are apparent in each individual. Infants with nemaline myopathy may benefit from a program involving mild-to-moderate, low-impact exercise, massage, and stretching techniques.

What is the prognosis for someone with nemaline myopathy?

Most people with nemaline myopathy are able to walk, although some affected children may begin walking later than usual. As the condition progresses, some people may require wheelchair assistance. In severe cases, the muscles used for breathing are affected and life-threatening breathing difficulties can occur.

Who discovered myopathy?

In 1963, Shy et al. (Brain 1963;86:793-810) and Conen et al. (Can Med Assoc J 1963;89:983-986) published the first description of a novel myopathy characterized by the aggregation of rods (nemaline bodies) in the muscle fibres. This disorder was subsequently known as nemaline myopathy.

What is nemaline myopathy 2 Neb?

Definition. Nemaline myopathy-2 (NEM2) is an autosomal recessive skeletal muscle disorder with a wide range of severity. The most common clinical presentation is early-onset (in infancy or childhood) muscle weakness predominantly affecting proximal limb muscles.

Does myopathy affect speech?

Bulbar muscle dysfunctions can be especially apparent in congenital myopathies (those present from birth), and can result in severe impairments to swallowing and speech abilities. Congenital myopathies also are characterized by developmental motor delays and, at times, facial or skeletal abnormalities.

How many people have nemaline myopathy?

Nemaline myopathy is a very rare disease that only affects 1 out of 50,000 on average, although recent studies show that this number is even smaller.

What medications are used for myopathy?

These myopathies are often treated with:

• Immunomodulatory/immunosuppressant drugs such as methotrexate, cyclosporine, tacrolimus, azathioprine, mycophenolate, rituximab and intravenous (IVIg) or subcutaneous (SubQIg) immunoglobulin.
• Corticosteroids such as prednisone or methylprednisolone.

What is the best treatment for myopathy?

What drugs can cause myopathy?

Direct myotoxicity – Examples include alcohol, cocaine, glucocorticoids, lipid-lowering drugs, antimalarials (which are associated with vacuolar myopathies), colchicine (which is associated with vacuolar myopathies), and zidovudine (which causes a mitochondrial myopathy).

What drugs cause drug-induced myopathy?

Is myopathy a neurological disorder?

Myopathy and myositis are neuromuscular conditions that cause muscle problems, such as stiffness or weakness. Many people with these conditions have not been diagnosed or may have been misdiagnosed with another illness.

What medications are used to treat myopathy?

How is drug induced myopathy treated?

Corticosteroids are the mainstay of treatment, but these drugs are burdened by several side effects. Thus, additional treatment based on immunosuppressive agents, especially azathioprine, methotrexate, mycophenolate mofetil and cyclosporine, is often needed.

Can drug induced myopathy be reversed?

In contrast to many other muscle diseases, drug-induced myopathy is potentially reversible if the offending drug is removed.

What drugs cause drug induced myopathy?

Does exercise help myopathy?

Exercise programmes to improve muscle strength, endurance and cardiovascular fitness have an important role in the overall management of patients with myopathy.