Is EGFR upregulated in cancer?
Table of Contents
Is EGFR upregulated in cancer?
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer, glioblastoma, head and neck cancer, pancreatic cancer, and breast cancer.
Why is EGFR important in cancer?
The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations (changes) in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly.
Is EGFR overexpressed in cancer?
EGFR is the most commonly expressed/overexpressed membranous oncogenic protein in cancer. The majority of EGFR overexpressing cancer patients are yet to benefit from current anti-EGFR therapeutics. Targeting the kinase activity of EGFR is preordained to acquired and innate resistance.
What is EGFR therapy?
Epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER-1) inhibitors are medicines that bind to certain parts of the EGFR and slow down or stop cell growth. EGFR is a protein that is found on the surface of some cells that causes cells to divide when epidermal growth factor binds to it.
How does overexpression of EGFR cause cancer?
At endosomes, EGFRs bind and phosphorylate the endosomal membrane‐associated protein, argonaute 2, a molecule involved in micro‐RNA (miRNA) maturation, causing inhibition of the maturation of tumor suppressor miRNAs, thus promoting cancer cell survival (Shen et al., 2013).
Is eGFR a tumor marker?
EGFR mutations as a prognostic and predictive marker in non-small-cell lung cancer – PMC.
What is abnormal EGFR?
Results. eGFR of 90 or higher is in the normal range. eGFR of 60 -89 may mean early kidney disease. eGFR of 15 -59 may mean kidney disease. eGFR below 15 may mean kidney failure.
What is the role of EGFR?
Normal Function The EGFR gene provides instructions for making a receptor protein called the epidermal growth factor receptor, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell.
