What are Ototoxins?

What are Ototoxins?

What Are Ototoxins? Exposure to certain chemicals in the workplace and medications can cause hearing loss or exacerbate the effects of noise. These chemicals and medications are considered ototoxic (oto = ear, toxic = poisonous). There are over 200 known ototoxic medications on the market today.

What are the most ototoxic drugs?

The most common reported ototoxic drugs in clinical use are aminoglycoside antibiotics, macrolide antibiotics, salicylates, chemotherapeutic agents such as cisplatin, loop diuretics, antimalarials, non-steroidal anti-inflammatory drugs (NSAIDs), quinine, and acetaminophen (Rybak & Ramkumar, 2007; Tabuchi et al., 2011; …

Is hearing loss from antibiotics permanent?

Hearing loss can be temporary but is usually irreversible with most agents. Generally, antibiotic-induced ototoxicity is bilaterally symmetrical, but it can be asymmetrical. The usual time of onset is often unpredictable, and marked hearing loss can occur even after a single dose.

What causes ototoxicity?

Ototoxicity is when a person develops hearing or balance problems due to a medicine. This can happen when someone is on a high dose of a drug that treats cancer, infections, or other illnesses. When doctors find ototoxicity (oh-tuh-tok-SISS-ih-tee) early, they may be able to prevent it from getting worse.

What is the best antidepressant for tinnitus?

The types of antidepressants used in treating tinnitus‐related symptoms are most commonly tricyclic antidepressants (including amitriptyline, imipramine and nortriptyline). Newer drugs such as selective serotonin reuptake inhibitors (SSRIs) (e.g. fluoxetine, paroxetine or other heterocyclic compounds) can also be used.

What medications contain Ototoxins?

List of Ototoxic Medications

• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), including aspirin, ibuprofen, and naproxen.
• Certain antibiotics, including aminoglycosides.
• Certain cancer medications.
• Water pills and diuretics.
• Quinine-based medications.

Which antibiotic is most likely to cause damage to the ear?

The Problems with Certain Antibiotics Along with chemotherapy drugs, loop diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs), aminoglycoside antibiotics such as gentamicin are one of the most ototoxic groups of drugs regularly prescribed. Their use can lead to temporary or permanent hearing loss and tinnitus.

Does hearing repair itself?

But they can repair themselves, often within a matter of hours. The breaking of tip links is seen as one of the causes of the temporary hearing loss you might experience after a loud blast of sound (or a loud concert). Once the tip links regenerate, hair cell function usually returns to normal.

How do you get rid of Ototoxins?

How do you Treat Ototoxicity? There is no treatment to reverse the effects of ototoxicity. Sometimes, the ear may heal spontaneously when the treatment with the ototoxic drugs is completed or the drug or chemical exposure is stopped early.

What are symptoms of ototoxicity?

What are the Symptoms of Ototoxicity? Damage to the hearing organs can range from mild to profound hearing loss and may include tinnitus (ringing in the ears). If the balance organs are damaged, the individual may experience symptoms ranging from dizziness and nausea to imbalance and blurry vision (oscillopsia).

What causes tinnitus to get louder?

Loud Noises When you have tinnitus — or ringing in your ears — many things can make those sounds worse. One of the most obvious is noise. Loud sounds from things like machinery, headphones, and concerts can cause short-term ringing or permanent hearing loss.

Which antibiotic can cause deafness?

Which antibiotics can cause hearing loss?

• Streptomycin.
• Neomycin.
• Vancomycin.
• Amikacin (Amikin)
• Gentamicin (Garamycin)
• Kanamycin (Kantrex)
• Paromomycin (Humatin)
• Tobramycin (Tobi)

What foods are good for hearing loss?

7 Foods That Can Help Lower Your Risk of Hearing Loss

• Fish. Fish contains little fat and is full of omega-3, omega-6, and other essential minerals your body needs.
• Legumes.
• Bananas.
• Broccoli.
• Dark chocolate.
• Garlic.
• Whole grains.

Can ear drops damage hearing?

Over-the-counter Eardrops May Cause Hearing Loss Or Damage, Study Suggests. Summary: A new study has revealed that certain over-the-counter earwax softeners containing the active ingredient triethanolamine polypeptide oleate condensate (10%) can cause severe inflammation and damage to the eardrum and inner ear.